环氧合酶-2和血管内皮生长因子在食管癌中的表达及临床意义

目的探讨食管癌组织中环氧合酶乞（COX-2）和血管内皮生长因子（VEGF）的表达及临床意义。方法采用SP免疫组化法检测60例食管癌患者组织和20例正常食管黏膜标本中COX-2和VEGF蛋白的表达。结果60例食管癌组织中，COX-2阳性表达率为68．3％，VEGF为76．7％；均明显高于正常食管黏膜，差异有统计学意义（P〈0．05）。COX-2和VEGF在食管癌组织中的表达呈显著正相关（rs=0．526，P〈0．0001）。VEGF表达与食管癌区域淋巴结转移密切相关，COX-2和VEGF表达与食管癌的临床分期、组织分化程度、浸润深度等无明显相关性（P〉0．05）。结论COX-2蛋白和VEGF蛋白在食管鳞癌中均呈高表达，二者的表达呈显著正相关。VEGF与食管癌区域淋巴结转移有相关性。

Expression of COX-2 and VEGF in esophageal squamous cell carcinoma and their clinical significance

Objective To explore the expression of COX-2 and VEGF in esophageal squamous cell carcinoma and their clinical significance.Methods Expressions of COX-2 and VEGF were observed by streptavidin-peroxidase(SP) immunohistochemical staining method on 60 cases of esophageal squamous carcinoma and 20 cases of normal esophagus tissue.Results Of 60 cases esophageal carcinoma tissue,the positive rates of COX-2 and VEGF were separate 68.3% and 76.7%;were higher than normal esophagus tissue,there were significant differences(P<0.05).Through statistics analysis,there was close positive correlation between COX-2 and VEGF expression.The expression of VEGF had a positive correlation with the district lymph node metastasis state,Their expression of COX-2 and VEGF had no relationship with the patients’ clinical stage,histological differentiation,and depth of tumor,there were no statistically significant(P<0.05).Conclusions The expression of COX-2 and VEGF were both high-grade in esophageal squamous carcinoma.and their expression were significant positive correlation.The VEGF had a positive correlation with the district lymph node metastasis state.