| 抗HIV药物靶点CCR5及HIV对CCR5抑制剂的抗性 |
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| 引用本文： | 陈超,高向东,顾觉奋.抗HIV药物靶点CCR5及HIV对CCR5抑制剂的抗性[J].中国处方药,2012,0(1):26-29. |
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| 作者姓名： | 陈超 高向东 顾觉奋 |
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| 作者单位： | 中国药科大学生命科学与技术学院,江苏 南京 210009 |
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| 摘 要： | 趋化因子受体CCR5是细胞膜表面G蛋白偶联受体中的一员.HIV-1在体内与细胞融合时需要CCR5作为辅助受体介导.因此,CCR5可作为抗HIV-1药物的筛选靶点,目前已筛选出多种CCR5抑制剂.但随着CCR5抑制剂的使用,HIV-1对于这些抑制剂的抗性也逐渐产生,而抗性的产生机制还不明确.本文主要介绍CCR5介导HIV-1与细胞融合的机制及HIV-1对CCR5抑制剂的抗性产生机制.
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| 关 键 词： | CCR5 HIV-1 CCR5抑制剂 抗性 |
Anti-HIV Target and Resistance to CCR5 Inhibitors |
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| Authors: | CHEN Chao GAO Xiang-dong GU Jue-fen |
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| Affiliation: | 2 (Institute of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu 210009, China) |
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| Abstract: | CCR5, one of G-protein-coupled receptors, could help HIV-1 fuse cell in vivo. Therefore CCR5 could be used as an anti-HIV-1 target. Nowdays, some CCR5 inhibitors were developed. However, the resistance to CCR5 inhibitors derived from HIV-1, and the mechanism had not been known clearly. The fusion and resistance mechanism to CCR5 inhibitors were reviewed. |
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| Keywords: | CCR5 HIV-1 CCR5 inhibitor resistance |
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