Effect of continuous positive airway pressure on serum cystatin C among obstructive sleep apnea syndrome patients |
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| Authors: | Xiao-Bin Zhang Xing-Tang Jiang Qi-Chang Lin Xiao Chen Hui-Qing Zeng |
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| Affiliation: | 1. Department of Respiratory Medicine, Zhongshan Hospital, Xiamen University, No. 201, Hubin Nan Road, Siming District, Xiamen, 361004, Fujian, People’s Republic of China
2. Department of Respiratory Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, People’s Republic of China
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| Abstract: | Purpose The purpose of the present study was to evaluate the influence of continuous positive airway pressure (CPAP) on serum cystatin C, a novel biomarker of early renal impairment, among obstructive sleep apnea (OSA) patients. Materials and methods Newly diagnosed severe OSA patients who treated with CPAP for 3 months were enrolled from two sleep laboratories. Serum biomarkers of renal impairment, cystatin C, creatinine and estimated glomerular filtration rate (eGFR), were detected before and after CPAP treatment. Results A total of 39 severe OSA patients were enrolled, 29 (74.4 %) were male, and mean age was 51.2 ± 12.2 years. After CPAP treatment, there were no changes of creatinine and eGFR (77.80 ± 20.00 vs. 75.3 ± 16.60 and 98.69 ± 31.74 vs. 100.20 ± 28.30, all p > 0.05), but cystatin C declined significantly (0.87 ± 0.18 vs. 0.77 ± 0.21, p = 0.000). Conclusion CPAP can decrease cystatin C levels among severe OSA patients and may prevent the latent renal impairment. |
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