The effect of endostatin mediated by human mesenchymal stem cells on ovarian cancer cells in vitro |
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| Authors: | Jing Jiang Wei Chen Rujin Zhuang Tiefang Song Peiling Li |
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| Institution: | (1) Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Harbin Medical University, No. 246, Xue Fu Road, Nan Gang District, 150001 Harbin, Hei Longjiang, China;(2) Department of Cardiovascular Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Hei Longjiang, China; |
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| Abstract: | Introduction Endostatin is the most potent inhibitor of tumor angiogenesis. However, endostatin protein has a short half-time and virus-mediated
endostatin gene therapy has serious toxicity, which limits the application of endostatin in clinical therapy. Mesenchymal
stem cells (MSCs) are considered to be able to accumulate at the site of cancers with high specificity and may be used as
a new delivery of endostatin. |
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