Different optical properties between human hepatocellular carcinoma tissues and non-tumorous hepatic tissues <Emphasis Type="Italic">In Vitro</Emphasis> |
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Authors: | Yuan Yu Chaowen Xiao Kun Chen Jianwei Zheng Jun Zhang Xinyang Zhao Xinbo Xue |
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Institution: | Department of Biliary and Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University ofScience and Technology, Wuhan 430030, China |
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Abstract: | There has been an ongoing search for clinically acceptable methods for the accurate, efficient and simple diagnosis and prognosis
of hepatocellular carcinoma (HCC). Optical spectroscopy is a technique with potential clinical applications to diagnose cancer
diseases. The purpose of this study was to obtain the optical properties of HCC tissues and non-tumorous hepatic tissues and
identify the difference between them. A total of 55 tissue samples (HCC tissue, n=38; non-tumorous hepatic tissue, n=17) were surgically resected from patients with HCC. The optical parameters were measured in 10-nm steps using single-integrating-sphere
system in the wavelength range of 400 to 1800 nm. It was found that the optical properties and their differences varied with
the wavelength for the HCC tissue and the non-tumorous hepatic tissue in the entire wavelength range of research. The absorption
coefficient of the HCC tissue (1.48±0.99, 1.46±0.88, 0.86±0.61, 2.15±0.53, 0.54±0.10, 0.79±0.15 mm−1) was significantly lower than that of the non-tumorous hepatic tissue (2.79±1.73, 3.13±1.47, 3.06±2.79, 2.57±0.55, 0.62±0.10,
0.93±0.16 mm−1) at wavelengths of 400, 410, 450, 1450, 1660 and 1800 nm, respectively (P<0.05). The reduced scattering coefficient of HCC tissue (5.28±1.70, 4.91±1.54, 1.26±0.35 mm−1) and non-tumorous hepatic tissue (8.14±3.70, 9.27±3.08, 2.55±0.57 mm−1) was significantly different at 460, 500 and 1800 nm respectively (P<0.05). These results show different pathologic liver tissues have different optical properties. It provides a better understanding
of the relationship between optical parameters and physiological characteristics in human liver tissues. And it would be very
useful for developing a non-invasive, real-time, simple and efficient way for medical management of HCC in the future. |
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Keywords: | carcinoma hepatocellular optical properties integrating sphere |
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