Perinatal risk factors for early childhood onset type 1 diabetes in Austria – a population-based study (1989–2005) |
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Authors: | Thomas Waldhoer Birgit Rami Edith Schober the Austrian Diabetes Incidence Study Group |
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Institution: | Department of Epidemiology, Center of Public Health, Medical University of Vienna, Vienna, Austria;;and Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria |
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Abstract: | Background: To investigate the rapid increase in incidence of type 1 diabetes mellitus (T1DM) in children <5 yr in Austria. Methods: Data of children born between 1989 and 2005 (n = 444) from the T1DM children incidence registry were linked with birth certificates (n = 1 407 829). Results: Age of mother, level of education, birth weight, birth length, body mass index, and APGAR score at 10 min were not significant. Boys have about 25% higher risk than girls hazard ratio = 0.75, 95% confidence interval (CI): 0.62–0.91]. The risk of developing diabetes increases over time significantly (1989–1991 vs. 2001–2005, hazard ratio = 2.86, 95% CI: 2.07–3.94). The linear effect of parity is borderline significant (p = 0.045), with lower risks for second and later born siblings. Marital status is significant hazard ratio = 0.73, 95% CI: 0.57–0.90)]. Native-born children exhibit twice as high risk as non-native children (hazard ratio = 0.51, 95% CI: 0.37–0.71). Birth weight shows a positive but not significant effect on risk of T1DM. Conclusions: In this very young and rapidly increasing cohort of diabetic children <5 yr of age, no association with birth weight but with year of birth, gestational age, nationality and parity could be observed. |
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Keywords: | childhood incidence perinatal factors risk factors TIDM |
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