老年性黄斑变性的游标高敏视力特征

目的 探讨老年性黄斑变性(age-related macular degeneration，AMD)游标高敏视力(hyperacuity)的临床特征及其在AMD临床诊断 、治疗中的应用价值。 方法 采用自行研究设计的游标高敏视力检查系统软件，对23例AMD患者39只眼(干性型22只眼，湿性型17只眼)以及正常同龄对照组20例40 只眼进行高敏视力检查。受检者按要求判断计算机显示屏上活动光标与固定光标的相对位置关系，并通过移动轨迹球调整光标，计算机自动分析活动光标和固定光标位置之偏差，得出 平均阈值及其变异度。 结果 萎缩型、渗出型AMD的高敏视力阈值以及阈值变异度的变化范围均大于正常同龄对照组；正常同龄对照组、萎缩型AMD、渗出型AMD 两两比较，其高敏视力阈值及阈值变异度间差异均有非常显著性的意义(P＜0.01)。三组方差分析具有统计学意义(P＜0.01)。两型AMD患者的视力与视力阈值的相关系数为-0.78，与高敏视力阈值变异度的相关系数为-0.80(P＜0.01)。 结论 高敏视力阈值及其变异度是反映萎缩型、渗出型AMD眼视功能的一个可靠指标。对于协助AMD的诊断、分类、动态观察病情、估计预后有一定的临床参考价值。 （中华眼底病杂志，2003，19：201-268）

The characteristic of vernier acuity on age-related macular degeneration patients

Objective To investigate the clinical characteristic of vernier acuity in age-related macular degeneration (AMD) patients. Methods The vernier acuity test soft wear system was developed to detect the 23 cases (39 eyes) of AMD patients. Tweenty-one eyes were atrophic type and 17 eyes were exudative type. Two fixed targets and a movable target are shown on the computer screen. The examinee was asked to adjust the position of the central target and the relationship between it and align them by using a track ball. The computer automatically recorded the deviations of distances between the movable target and the specific one, and then computed and analysed the results of average threshold and variance. Results Both the atrophic and exudative AMD had higher vernier acuity threshold and its variance than normal subjects, and the differences were significant (P<0.01). The correlation coefficient between visual acuity and vernier acuity threshold was -0.78, and that between visual acuity and threshold variance was -0.80. The results suggest that vernier acuity threshold and its variance were reliable parameters that reflect the visual acuity in AMD patients. Conclusions The results suggest that vernier acuity threshold and its variance were reliable parameters that reflect the visual acuity in AMD patients.