A role for accessory genes rI.-1 and rI.1 in the regulation of lysis inhibition by bacteriophage T4 |
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Authors: | Piotr Golec Aleksandra Wiczk Anna Majchrzyk Joanna M. Łoś Grzegorz Węgrzyn Marcin Łoś |
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Affiliation: | (1) Department of Molecular Biology, University of Gdańsk, Kładki 24, 80-822 Gdańsk, Poland;(2) Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland; |
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Abstract: | Lysis inhibition (LIN) is a known feature of the T-even family of bacteriophages. Despite its historical role in the development of modern molecular genetics, many aspects of this phenomenon remain mostly unexplained. The key element of LIN is an interaction between two phage-encoded proteins, the T holin and the RI antiholin. This interaction is stabilized by RIII. In this report, we demonstrate the results of genetic experiments which suggest a synergistic action of two accessory proteins of bacteriophage T4, RI.-1, and RI.1 with RIII in the regulation of LIN. |
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