Differential Pathologic Variables and Outcomes across the Spectrum of Adenocarcinoma of the Esophagogastric Junction |
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| Authors: | John V. Reynolds Narayanasamy Ravi Cian Muldoon John O. Larkin Suzanne Rowley Ken O’Byrne Donal Hollywood Dermot O’Toole |
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| Affiliation: | (1) Department of Surgery, St. James’s Hospital and Trinity College Dublin, Trinity Center, Dublin 8, Ireland;(2) Department of Pathology, St. James’s Hospital, Dublin 8, Ireland;(3) Academic Unit of Clinical and Medical Oncology, Trinity College Dublin, Dublin 8, Ireland;(4) Department of Medicine, Trinity College Dublin, Dublin 8, Ireland |
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| Abstract: | Background Adenocarcinoma of the esophagogastric junction (AEG) as described by Siewert et al. is classified as one entity in the latest (7th Edition) American Joint Cancer Committee/International Union Against Cancer (AJCC/UICC) manual, compared with the previous mix of esophageal and gastric staging systems. The origin of AEG tumors, esophageal or gastric, and their biology remain controversial, particularly for AEG type II (cardia) tumors. |
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