Cardiac and skeletal muscle scintigraphy in dermato- and polymyositis: Clinical implications |
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Authors: | Carlos A. Buchpiguel Sueli Roizemblatt Elda H. Pastor Fausto H. Hironaka Wilson Cossermelli |
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Affiliation: | (1) Centro de Medicina Nuclear, Departamento de Radiologia, Faculdade de Medicina da USP, Cx Postal 11136, CEP 05422-970 São Paulo-SP, Brasil;(2) Department of Rheumatology, São Paulo University School of Medicine, São Paulo, Brazil |
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Abstract: | To determine the role of scintigraphy in the detection of skeletal and cardiac involvement in dermato-and polymyositis (DM/PM), we studied 30 patients with a confirmed diagnosis of DM/PM (23 females, 7 males; mean age: 35 years). Technetium-99m pyrophosphate (99mTc-PYP) and gallium-67 scans showed similar sensitivity, specificity and accuracy in the detection of skeletal muscle involvement when compared with serum enzymes (70%, 100% and 80%, respectively). Compared with the clinical parameters,99mTc-PYP showed 70% and67Ga 65% accuracy. Abnormal PYP cardiac uptake was observed in 57% of patients, whereas abnormal67Ga cardiac uptake was seen in only 15%. Electrocardiography was abnormal in 40%, rest gated blood pool study in 23%, and chest X-ray in 13%. In conclusion, both99mTc-PYP and67Ga can be useful in the detection of the active phase of muscle disease. However,99mTc-PYP seems to be more effective than67Ga in the early diagnosis of cardiac involvement. |
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Keywords: | Polymyositis/dermatomyositis Cardiac imaging Technetium-99m pyrophosphate Musculoskeletal imaging Gallium-67 Gated blood pool |
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