前列安通片对BPH大鼠前列腺组织中 VEGF，bFGF表达的影响

目的：观察前列安通片对前列腺增生(BPH)大鼠增生前列腺组织的影响，并探讨其作用机制。方法：采用SD大鼠去势后皮下注射丙酸睾丸酮法复制BPH模型，用形态计量学方法研究各组前列腺组织的形态改变；用免疫组化法研究实验各组前列腺组织的血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)的表达。结果：前列安通片高、中、低各剂量组(6.24，3.12，1.56 g·kg-1)及阳性药保列治组(1.67 g·kg-1)与模型组比较，前列腺质量、前列腺体积、前列腺指数均明显降低(P<0.01)；腺体平均面积、平均周长降低，相同面积内腺体总数目增加(P<0.01)；前列安通片各剂量组bFGF表达显著低于模型组(P<0.01)，高剂量组前列腺组织中VEGF表达明显低于模型组(P<0.05)。结论：前列安通片能缩小前列腺体积，对BPH有一定的治疗作用，作用机制与抑制VEGF，bFGF的表达有关。

Influence of Qianlie Antong tablets on expresstion of VEGF and bFGF in protatic tissues of BHP rats

Objective: To evaluate the effect of Qianlie Antong tablet (QLAT) on the tissues of benign prostatic hyperplasia (BPH) of experimental rats, and seek its mechanism. Method: The animal model of BPH was made with rats by subcutaneously injecting methylacetic acid testosterone after emasculated. The changes of prostatic tissues of every group are studied with morphometry combining the immunohistochemistry method, the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in prostate tissue were examine. Result: QLAT can diminish the gland weight, volume and index of prostate, compared with control group, and alse can decrease average area and circumference of gland, and increase the amount of total glands in equal area. Meanwhile, the expresstion of bFGF and VEGF in prostatic tissues were decreased in GANT groups, compared with control group. Conclusion: QLAT can diminish the prostate gland volume, which may be attained by inhibiting the expression of VEGF and bFGF in prostatic tissue.