hs-CRP、Fib、NT-proBNP在COPD合并肺动脉高压中的研究及意义

目的观察C反应蛋白(hs-CRP)、纤维蛋白原(Fib)、N-端脑钠肽前体(NT-proBNP)在慢性阻塞性肺病(COPD)合并肺动脉高压患者血液中的变化,分析相关性及意义。方法选取我院COPD患者105例,分A组(单纯COPD组,55人)、B组(COPD合并肺动脉高压组,50人)。行肺功能、心脏彩超检查,检测hs-CRP、NT-proBNP、Fib及血气分析。结果 hs-CRP、Fib、NT-proBNP在B组均高于A组(均P0.05);PaCO2、hs-CRP、Fib、NT-proBNP水平与肺动脉压呈正相关;PaCO2、hs-CRP、Fib与NT-proBNP呈正相关。结论hs-CRP、Fib、NT-proBNP参与了COPD合并肺动脉高压的形成,全身炎症在COPD继发肺动脉高压的发病中发挥重要作用。

Significance of bio-markers in chronic obstructive pulmonary disease patients complicated with pulmonary hypertension

Objective To observe the changes of hypersensitive C-reactive protein （hs-CRP）, Fibrinogen （Fib）, N-terminal fragment of pro-brain natriuretic peptide （NT-proBNP） in COPD patients complicated with pulmonary hypertension （PH）. Methods 105 patients with COPD were enrolled in our hospital. 55 patients were classified as the group A （ COFD without PH） and 50 patients as the group B （ COPD with PH）. Pulmonary pressure was assessed by Doppler echocardiography, FEV1% and FEVJFVC by lung function test. The expression of hs-CRP, NT-proBNP and Fib and arterial blood gas analysis were measured. Results The levels of hs-CRP, Fib and NT- proBNP in the group B were significantly higher than in the group A （P 〈 0.05）. The levels of PaCO2, hs-CRP, Fib and NT-proBNP were positively correlated with pulmonary pressure （ P 〈 0. 05 ）. The levels of PaCO2, hs-CRP and Fib were positively correlated with NT-proBNP （ P 〈 0. 05）. Conclusion The levels of hs-CRP, Fib, NT-proBNP are positively related to PH in COPD patients, suggesting that systemic inflammation plays a role in the pathogenesis of PH in COPD.