| OSAHS患者呼出气冷凝液中MMP-9的变化 |
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| 引用本文： | 徐健,李一禄,陈济明,徐晓妮,何梦颖. OSAHS患者呼出气冷凝液中MMP-9的变化[J]. 临床肺科杂志, 2014, 0(9): 1678-1679 |
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| 作者姓名： | 徐健 李一禄 陈济明 徐晓妮 何梦颖 |
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| 作者单位： | 徐健 (广东医学院附属南山医院呼吸内科, 广东 深圳,518052)； 李一禄 (广东医学院附属南山医院呼吸内科, 广东 深圳,518052)； 陈济明 (广东医学院附属南山医院呼吸内科, 广东 深圳,518052)； 徐晓妮 (广东医学院附属南山医院呼吸内科, 广东 深圳,518052)； 何梦颖 (广东医学院附属南山医院呼吸内科, 广东 深圳,518052)； |
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| 摘 要： | 目的观察阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者呼出气冷凝液(EBC)中基质金属蛋白酶9(MMP-9)的变化。方法选取男性40例OSAHS患者为实验组,30例年龄、体重指数等均相匹配的健康查体者为对照组,用ELISA检测EBC中MMP-9水平。结果和对照组比较,OSAHS组EBC中MMP-9明显升高,有显著统计学意义(P0.05)。MMP-9与AHI呈正相关,与最低SaO2负相关(P均0.05)。结论OSAHS患者EBC中MMP-9水平可反映OSAHS病情的严重程度。
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| 关 键 词： | 阻塞性睡眠呼吸暂停低通气综合征 呼出气冷凝液 基质金属蛋白酶- |
Changes of MMP-9 in exhaled breath condensate of patients with obstructive sleep apnea hypopnea syndrome |
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| XU Jian,LI Yi-lu,CHEN Ji-ming,XU Xiao-ni,HE Meng-ying. Changes of MMP-9 in exhaled breath condensate of patients with obstructive sleep apnea hypopnea syndrome[J]. Journal of Clinical Pulmonary Medicine, 2014, 0(9): 1678-1679 |
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| Authors: | XU Jian LI Yi-lu CHEN Ji-ming XU Xiao-ni HE Meng-ying |
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| Affiliation: | (Department of Respiratory Disease, the Affiliated Nanshan Hospital of Guangdong Medical College, Shenzhen , Guangdong 518052, China) |
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| Abstract: | Objective To evaluate the changes of matrix metalloproteases-9（MMP-9）in exhaled breath con-densate（ EBC） with Obstructive sleep apnea-hypopnea syndrome （ OSAHS） . Methods Select 40 males and OSAHS patients for the experimental group, 30 healthy subjects matched age and body mass index as a control group. exhaled breath condensate The levels of MMP-9 in EBC were determined by ELISA. Results Compared to the control group, the MMP-9 in OSAHS group was significantly higher （ P〈0. 05 ） . MMP-9 was positively correlated with AHI （ P〈0. 05）, and negative correlated the lowest SaO2（P〈0. 05）. Conclusion The MMP-9 levels in EBC in OSAHS pa-tients may reflect the severity of OSAHS. |
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| Keywords: | obstructive sleep apnea hypopnea syndrome exhaled breath condensate |
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