诱导活化肝星状细胞凋亡主要信号通路的研究进展

肝纤维化是各种病因引起的肝脏慢性进行性的病理过程,肝纤维化时细胞外基质(ECM)合成大于降解导致ECM在肝内大量沉积。肝星状细胞(HSC)的激活、转化并产生分泌大量ECM是肝纤维化形成的关键环节。而通过诱导活化的HSC发生凋亡是逆转肝纤维化的重要手段之一。就主要的凋亡信号通路:死亡受体通路、线粒体通路、内质网通路、神经生长因子通路进行一一阐述。指出了对活化HSC的凋亡途径进行选择性的药物干预有望发挥抗肝纤维化的作用。

Research advances in main signaling pathways for inducing apoptosis of activated hepatic stellate cells

Hepatic fibrosis is a chronic progressive pathological process of the liver induced by various cases. When hepatic fibrosis devel- ops, a large amount of extracellular matrix （ECM） is deposited in the liver due to the fact that the synthesis of ECM is greater than its degradation. The key step in the development of hepatic fibrosis is the activation and transformation of hepatic stellate cells （HSC） and secretion of a large amount of ECM. One of the important means for reversing hepatic fibrosis is to induce the apoptosis of activated HSC. The main apoptotic signaling pathways, death receptor pathway, mitochondrial pathway, endoplasmic reticulum pathway, and nerve growth factor path- way, are reviewed. Selective drug intervention for the apoptotic signaling pathways of activated HSCs is expected to reverse hepatic fibrosis.