帕利哌酮缓释片对酒精所致精神病性障碍患者精神症状及生活质量的疗效观察

目的 探讨帕利哌酮缓释片对酒精所致精神病性障碍患者精神症状及生活质量的疗效及安全性。方法 收集50例酒精所致精神病性障碍患者，随机分为研究组和对照组，研究组使用帕利哌酮缓释片，对照组使用氟哌啶醇片，研究时间为6周，运用阳性与阴性症状量表(PANSS)、生活质量指数问卷(QL-Index)和副反应量表(TESS)对2组患者进行疗效及不良反应的评定。结果 研究组有效率为72%，显著高于对照组的60%(P<0.05)。研究组PANSS评分在入组后第1周较入组时有显著性下降，QL-Index评分在入组后第1周较入组时有显著提高(P<0.05)。与对照组相比，研究组PANSS评分在入组后第1周阳性分及总分显著降低，在入组后第2，4，6周时阳性分、阴性分及总分均显著降低(P<0.05)；QL-Index评分在入组后第1，2，4，6周时均显著升高；研究组TESS评分在入组后第1，2，4，6周时均显著降低。结论 帕利哌酮缓释片在改善酒精所致精神病性障碍患者精神症状、生活质量及安全性等方面优于氟哌啶醇。

Efficacy of Paliperidone Extended-release Tablets for the Psychiatric Symptoms and Life Quality in Patients with Alcohol-induced Mental Disorders

OBJECTIVE To study the efficacy and safety of Paliperidone Extended-release tablets in the treatment of alcohol-induced mental disorders. METHODS Fifty cases of alcohol-induced mental disorders were randomly divided into the study group and the control group. In study group, patients were treated with Paliperidone Extended-release tablets, while in control group, patients were treated with haloperidol. The study period was 6 weeks. After 1, 2, 4, 6 weeks of treatment, positive and negative symptom scale(PANSS), quality of life index questionnaire(QL-Index) and treatment emergent symptom scale(TESS) were assessed for all patients to evaluate the effect and adverse reactions. RESULTS The therapeutic effect rate of study group was 72%, while the control group was 60%, this difference was significant(P<0.05). PANSS scores in the study group decreased significantly from 1st week, while those in control group decreased starting from the 2nd week; QL-Index scores in the study group increased significantly from 1st week, while those in the control group increased from 2nd week. After treatment of 1, 2, 4, 6 weeks, the scores of PANSS of the study group were lower than those in the control group, and the QL-Index scores of the study group were higher than those in the control group. The TESS scores in the study group were significantly less than that in control group after 1, 2, 4, 6 weeks. CONCLUSION Paliperidone Extended-release tablets is superior to haloperidol in the treatment of mental disorders duo to alcohol with better efficacy and safety.