中药单体对乳膏物理稳定性的影响机制探讨

该文分别以结构母核相近的黄酮类及生物碱类中药单体为乳膏所载药物,以稳定的山梨醇酐单硬脂酸酯(司盘60)-聚氧乙烯脱水山梨醇单油酸酯(吐温80)乳化体系为乳膏基质,采用近红外稳定性分析技术定量表征乳膏的物理稳定性,基于乳膏凝胶网状结构理论、溶度参数理论、双电层理论、界面膜理论,探寻中药单体对乳膏物理稳定性的影响机制。结果表明,延胡索乙素、苦参碱、柚皮素、氧化苦参碱中药单体与乳膏基质辅料具有接近的溶度参数,其制备的乳膏具有较高的Zeta电位值,较强的物理稳定性,且与基质乳膏具有较为接近的微观结构信息;而黄芩苷、小檗碱、黄藤素、黄芩素中药单体与乳膏基质辅料的溶度参数差异较大,其制备的乳膏具有较低的Zeta电位值,较差的物理稳定性,且与基质乳膏的微观结构信息差异较大。

Discussing of influence mechanism of Chinese herbal monomer on physical stability of cream

This study left flavonoids and alkaloids Chinese herbal monomer with common parent nucleus as cream base carriages drug respectively, cream base were prepared with stable span 60-tween 80 emulsification system. The near-infrared stability analysis technology was performed to quantitatively characterize the physical stability of cream. Base on the theory of gel network structure, theory of emulsification, theory of solubility parameter and theory of double layer, the influence mechanism of Chinese herbal monomer on physical stability of cream was discussed. The results showed that tetrahydropalmatine, matrine and naringenin had similar solubility parameter value with cream base material, creams prepared with those Chinese herbal monomer have higher Zeta potential value and stronger physical stability, and that those creams had similar microstructure information with cream base. However, a larger solubility parameter difference exists between baicalin, baicalein, berberine, palmatine and cream base material. Creams prepared with those Chinese herbal monomers had lower Zeta potential value and poorer physical stability, and that those creams had great different microstructure information with cream base.