双能CT碘含量分析早期诊断兔肝VX2肿瘤射频消融治疗后残癌

目的 探讨双能CT碘含量分析早期诊断兔肝VX2肿瘤射频消融（RFA）治疗后残癌的价值。方法 选取健康新西兰大白兔24只，建立兔肝VX2移植瘤模型，行不完全RFA，于消融治疗后第3（A组）、7（B组）、14（C组）、21天（D组）行双能CT多期增强扫描及碘含量分析，然后处死模型兔，进行病理学检查，比较不同时间点残癌与及炎症带碘摄取值的差异。结果 RFA术后，C组动脉期、D组动脉期及静脉期残癌的碘浓度和标准碘浓度均明显高于炎症反应区碘浓度值（P均<0.05）。A组、B组残癌与炎症反应区碘浓度及标准碘浓度的差异均无统计学意义（P均>0.05）。结论 双能CT碘含量分析有助于兔肝VX2肿瘤模型RFA治疗后残癌的早期诊断。

Dual-energy CT iodine quantification in early diagnosis of residual tumor in rabbits with transplanted hepatic VX2 carcinoma after radiofrequency ablation

Objective To explore the value of dual-energy CT (DECT) iodine quantification in early diagnosis of residual tumor in rabbits with transplanted hepatic VX2 carcinoma after radiofrequency ablation (RFA). Methods Twenty-four New Zealand rabbits were selected to establish hepatocellular carcinoma models by implanting VX2 tumor fragments into liver. DECT iodine quantification were performed 3th (group A), 7th (group B), 14th (group C) and 21st day (group D) after incomplete RFA (each n=6). And then the pathological examination were performed to differentiate benign periablational reactive tissue from residual tumor, and the differences of iodine concentration were compared between them. Results The iodine concentration and normalized iodine concentrations (lesion-to-aorta iodine ratio) of residual tumor were significantly higher than those of benign periablational reactive tissue in group C during the arterial phase, group D during both the arterial phase and the portal venous phase (all P<0.05), but there was no significant difference in group A and group B (all P>0.05). Conclusion DECT iodine quantification is helpful for early diagnosis of residual tumor in rabbits with transplanted hepatic VX2 carcinoma after RFA.