原发性肺癌中医证型规律与化疗及靶向治疗的相关性研究

目的：研究原发性肺癌患者中医证型分布规律及其与化疗及靶向治疗之间的相关性，为肺癌中医证型研究与临床应用提供理论支持。方法：采用统一的中医证型调查表对上海中医药大学附属龙华医院肿瘤科和上海市肺科医院中医科的肺癌患者进行中医辨证，分析肺癌中医证型分布规律，另对病例中的上海市肺科医院患者分析，探讨肺癌不同中医证型分布规律与化疗及靶向之间的相关性。结果：①原发性肺癌患者中医证型以肺阴虚证、肺气虚证、瘀阻肺络证、脾气虚证、肺阴虚火旺证为主；②肺癌中医证型演变与不同治疗方法存在一定的相关性，其中靶向治疗对肺阴虚证的影响较为显著（P＜0.05），主要表现为靶向治疗后肺阴虚证明显增多。结论：①肺癌中医证型分布具有一定规律，以肺阴虚证、肺气虚证、瘀阻肺络证、脾气虚证、肺阴虚火旺证为主；②肺癌中医证型演变与靶向之间存在一定的相关性，主要表现为靶向治疗后肺阴虚证明显增多。

Relevance Research between Traditional Chinese Medicine Syndromes and Chemotherapy and Targeted Therapy on Primary Lung Cancer

This article was aimed to study the relevance between traditional Chinese medicine (TCM) syndromes and the treatment of chemotherapy and targeted therapy, in order to provide theoretical support for TCM syndromes of lung cancer in the clinical application. Uniform TCM syndromes questionnaire was used in the TCM syndrome differentiation among lung cancer patients from the Oncology Department of Longhua Hospital, Shanghai University of Traditional Chinese Medicine and TCM Department of Shanghai Pulmonary Hospital. The analysis was made on correlation between distribution rules of TCM syndromes and chemotherapy and targeted therapy. The results showed that among primary lung cancer patients, the most TCM syndromes were syndrome of lung-yin deficiency, lung-qi deficiency, blood stasis in lung collaterals, spleen-qi deficiency, lung-yin deficiency with fire excess. There were certain correlation in TCM syndromes and different TCM therapeutic methods, in which targeted therapy had great significant effect on syndrome of lung-yin deficiency (P < 0.05), after targeted therapy syndrome of lung-yin deficiency increased obviously. It was concluded that there were some regulations in TCM syndromes of lung cancer which take syndrome of lung-yin deficiency, lung-qi deficiency, blood stasis in lung collaterals, spleen-qi deficiency, lung-yin deficiency with fire excess. There were certain correlation in TCM syndromes and different TCM therapeutic methods, after targeted therapy syndrome of lung-yin deficiency increased obviously.