绵枣儿中高异黄酮和二苯乙烯类化合物

绵枣儿来源于风信子科植物绵枣儿Scilla scilloides(Lindl.)Druce的鳞茎。本研究采用HPD100大孔树脂、硅胶、Sephadex LH-20、ODS柱色谱和半制备HPLC等方法,从采自河南信阳的绵枣儿中分离出17个化合物;根据化合物的理化性质和波谱数据,分别鉴定为2-羟基-7-甲氧基绵枣儿素(1),绵枣儿素(2),5,7-dihydroxy-3’,4’-dimethoxyspiro{2H-1-benzopyran-7’-bicyclo[4.2.0]octa[1,3,5]-trien}-4-one(3),socialinone(4),4-甲基白藜芦醇(5),(E)-白藜芦醇(6),scillavone A(7),3,9-dihydroeucomnalin(8),3-(3-羟基-4-甲氧基苄基)-5,7-二羟基苯并二氢吡喃-4-酮(9),(3R)-5,7,3’-trihydroxy-4’-methoxyspiro{2H-1-benzopyran-7’-bicyclo[4,2,0]octa[1,3,5]-trien}-4-one(10),scillabene A(11),2-羟基绵枣儿素(12),3-(4-羟基苄基)-5,7-二羟基苯并二氢吡喃-4-酮(13),3-(4-羟基亚苄基)-5,7-二羟基苯并二氢吡喃-4-酮(14),3-(4-羟基苄基)-5-羟基-7,8-二甲氧基苯并二氢吡喃-4-酮(15),3-(4-羟基苄基)-5-羟基-6,7-二甲氧基苯并二氢吡喃-4-酮(16),3-(4-羟基苄基)-5,8-二羟基-7-甲氧基苯并二氢吡喃-4-酮(17),其中化合物3,4,6,9,13和15~17为首次从绵枣儿植物中分离得到。

Homoisoflavanones and stilbenes from fresh bulb of Scilla scilloides

Mian-Zao-Er was collected from the bulbs of Scilla scilloides (Lindl.) Druce, belonging to the Hyacinthaceae family. 17 compounds were obtained using various column chromatographies on macroporus resin (HPD100), silica gel, Sephadex LH-20 and ODS, as well as semi-preparative HPLC. Their structures were elucidated on the basis of physicochemical properties and spectral data as 2-hydroxy-7-methoxyscillascillin (1), scillascillin (2), 5,7-dihydroxy-3',4'-dimethoxyspiro{2H-1-benzopyran-7'-bicyclo octa -trien}-4-one (3), socialinone (4), 4-methylresveratrol (5), (E)-resveratrol (6), scillavoneA (7), 3,9-dihydroeucomnalin (8), 3-(3-hydroxy-4-methoxybenzyl)-5,7-dihydroxychroman-4-one (9), (3R)-5,7,3'-trihydroxy-4'-methoxyspiro{2H-1-benzopyran-7'-bicyclo octa -trien}-4-one (10), scillabene A (11), 2-hydroxyscillascillin (12), 3-(4-hydroxybenzyl)-5,7-dihydroxychroman-4-one (13), 3-(4-hydroxybenzylidene)-5,7-dihydroxychroman-4-one (14), 3-(4-hydroxybenzyl)-5-hydroxy-7,8-dimethoxychroman-4-one (15), 3-(4-hydroxybenzyl)-5-hydroxy-6,7-dimethoxychroman-4-one (16),and 3-(4-hydroxybenzyl)-5,8-hydroxy-7-methoxychroman-4-one (17). Among them, compounds 3, 4, 6, 9, 13 and 15-17 were isolated from this plant for the first time.