| t（14；18）阴性滤泡性淋巴瘤的分子遗传学机制及研究进展 |
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| 引用本文： | 潘毅. t（14；18）阴性滤泡性淋巴瘤的分子遗传学机制及研究进展[J]. 中国肿瘤临床, 2011, 38(21): 1355-1358. DOI: 10.3969/j.issn.1000-8179.2011.21.014 |
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| 作者姓名： | 潘毅 |
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| 作者单位： | 天津市肿瘤防治重点实验室,天津医科大学附属肿瘤医院病理科 (天津市300060) |
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| 摘 要： | 滤泡性淋巴瘤（FL）是生发中心起源的低级别B细胞非霍奇金淋巴瘤。最具特征性的遗传学改变是染色体14q32上的免疫球蛋白重链基因（IgH）和染色体18q21上的Bcl-2基因的平衡转位，形成t（14；18）（q32；q21）。此转位使Bcl-2蛋白过度表达。在功能上延长了细胞的生存时间并导致FL的形成。t（14；18）并不是出现于所有FL病例中，大约90%的FL存在t（14；18），其余的FL未能检测到该转位。t（14；18）的存在与否与滤泡性淋巴瘤的发生和发展密切相关。
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| 关 键 词： | 滤泡性淋巴瘤 t（14 18）阳性 t（14 18）阴性 |
| 收稿时间： | 2011-03-01 |
Molecular Genetic Pathogenesis and Research Advances in Follicular Lymphoma without (14;18)Translocation |
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| Yi PAN. Molecular Genetic Pathogenesis and Research Advances in Follicular Lymphoma without (14;18)Translocation[J]. Chinese Journal of Clinical Oncology, 2011, 38(21): 1355-1358. DOI: 10.3969/j.issn.1000-8179.2011.21.014 |
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| Authors: | Yi PAN |
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| Affiliation: | Department of Pathology, Cancer Institute and Hospital of Tianjin Medical University, Key Laboratory of Prevention and Treatment of Cancer of Tianjin City, Tianjin 300060, China |
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| Abstract: | Follicular lymphoma ( FL ) is a low-grade B-cell non-Hodgkin's lymphoma of germinal center origin. The genetic hallmark of FL is the chromosomal translocation between the immunoglobulin heavy-chain gene on chromosome 18 and the Bcl-2 gene on chromosome 14. The resultant t ( 14;18 ) ( q32;q21 ) leads to the constitutive overexpression of Bcl-2 protein. Functionally, this phenomenon results in the prolongation of cell survival and lymphomagenesis. However, the translocation of t ( 14;18 ) is not present in all FL cases. Approximately 90% of all FLs carry this characteristic alteration; in the remaining cases, t ( 14; 18 ) is not detectable. The presence or absence of t ( 14; 18 ) is closely linked to the occurrence and development of FLs. |
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