孕妇血清铁锌水平与镉毒效应关系

目的 探讨孕妇和非孕妇体内铁、锌状态与镉水平及其毒作用间的相关性。方法 对98名孕妇和73名非孕妇分别测定血镉(BCd)、血清铁(SFe)、血清锌(SZn)、血红蛋白(Hb)、血清铁蛋白(SF)、尿镉(UCd)、尿金属硫蛋白(UMt)、尿β₂-微球蛋白(Uβ₂-MG)、N-乙酰-β-D-氨基葡萄糖苷酶(UNAG),并进行相关分析。结果 孕妇组SZn、Hb、SF含量均明显低于非孕妇组,而UCd、BCd、UMt、Uβ₂-MG、UNAG、低SZn率、贫血率均高于非孕妇组;分血组BCd、UCd、UMt、Uβ₂-MG、UNAG均高于非贫血组;UNAG、Uβ₂-MG随血锌增加而降低;孕妇组镉毒效应随尿镉增高而升高;Hb与UCd、BCd、Uβ₂-MG和UMt呈负相关;SF与UCd呈负相关;SZn与UNAG、UMt、Uβ₂-MG呈负相关。结论 缺铁能促进镉吸收,使镉进入体内的量增加;锌对镉引起的肾损伤有拮抗作用。

Correlation between status of ferrum, zinc and toxicity of cadmium in pregnant women

Objective To investigate the correlation between ferrum and zinc status and toxic effects of cadmium in pregnant women.Methods BCd,SFe,SZn,Hb,SF,U Cd,UMt,Uβ₂-MG and UNAG in the blood,serum or urine were measured in 98 pregnant women and 73 non-pregnant women.Correlation analysis was carried out.Results The contents of SZn,Hb and SF were lower,but the contents of UCd,BCd,UMt,Uβ₂-MG,UNAG,percentage of anemia and low SZn in the pregnant women were higher than that in non-pregnant women.The contents of BCd,UCd,UMt,Uβ₂-MG and UNAG were higher in anemia group than that in non-anemia group.With the increase of SZn content,UNAG and Uβ₂-MG decreased and toxic effect of Cd increased with the increase of UCd content.Hb was negatively correlated with UCd,BCd,Uβ₂-MG and UMt.SF was negatively correlated with UCd.Meanwhile,SZn was negatively correlated with UNAG,UMt and Uβ₂-MG.Conclusion Ferrum deficiency can promote the absorption of cadmium,and zinc can antagonize the injury caused by cadmium in kidney.