鼻部和咽部T／NK细胞淋巴瘤具有明显的肿瘤血管生成活性

目的研究鼻部和咽部T/NK细胞淋巴瘤和B细胞淋巴瘤肿瘤血管生成活性的差别.方法用CD56及CD45RO识别T/NK细胞淋巴瘤,用CD20识别B细胞淋巴瘤,用CD34识别肿瘤内微血管,研究61例鼻部和咽部淋巴瘤的免疫表型及肿瘤内微血管密度(intratumoralmicrovessel

Nasal/nasopharyngeal T/NK-cell lymphomas with evident angiogenic activity

OBJECTIVE: To search the difference of the angiogenic activity between T/NK-cell lymphomas and B-cell lymphomas. METHODS: The T/NK-cell was stained immunohistochemically by CD56 and CD45 RO, the B-cell was by CD20, the microvessel endothelium was by CD34. Sixty-one cases were studied to examine the immunophenotype and to estimate the intratumoral microvessel density (iMVD). RESULTS: Forty in 61 cases (65.6%) expressed the immunophenotype of both T-cell and Natural Killer cell, were diagnosed T/NK-cell lymphomas. Fifteen in 61 cases (24.6%) expressed the immunophenotype of B-cell. There was a significant difference in incidence between the two types of lymphomas (chi 2 = 22.4, P < 0.01). The mean of iMVD/HPF was 24.1 +/- 8.7 in 40 cases of T/NK-cell lymphomas, while the mean of iMVD/HPF was 14.9 +/- 3.8 in 15 cases of B-cell lymphomas. The difference (t = 3.7, P < 0.05) was significant. CONCLUSION: The angiogenic activity of T/NK-cell lymphomas is much more than that of B-cell lymphomas. This study shows nasal/nasopharyngeal T/NK-cell lymphomas are with evident angiogenic activity.