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The pharmacodynamic and pharmacokinetic interaction of flecainide acetate with propranolol: Effects on cardiac function and drug clearance |
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| Authors: | J. L. Holtzman D. C. Kvam D. A. Berry L. Mottonen G. Borrell L. I. Harrison G. J. Conard |
| Affiliation: | (1) Medical Service, VA Medical Center, 55417 Minneapolis, MN, USA;(2) Departments of Pharmacology and Medicine, University of Minnesota, 55455 Minneapolis, MN, USA;(3) Riker Laboratories Inc., 55144 St. Paul, MN, USA;(4) Department of Theoretical Statistics, University of Minnesota, 55455 Minneapolis, MN, USA |
| Abstract: | Summary The effect of aluminum phosphate on the bioavailability of ranitidine has been investigated in 10 young, healthy volunteers. Following a random cross over design, each subject took at a 1 week interval 150 mg ranitidine alone or with 11 g aluminum phosphate. Plasma and urine ranitidine levels were measured by HPLC. The antacid reduced both the maximum plasma ranitidine concentration by 40% and the area under the curve by 30%. Elimination of ranitidine was not changed. The results indicate that aluminum phosphate significantly diminished the bioavailability of ranitidine. |
| Keywords: | flecainide propranolol pharmacodynamics pharmacokinetics drug interaction |
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