药代动力学参数的计算机拟合及统计学评价

以残数法计算药代参数时,模型的选择可因主观影响,误差大,结果不恒定。我们在APPLEⅡ型微电脑上,采用非线性最小二乘法编程,大大提高了参数估计的精度,同时可对房室模型选择提供客观依据,并对参数作出统计学评价。程序采用菜单式结构,包括血管内、外各种模型,具有数据存取和较强的作图功能。

A NONLINEAR FITTING METHOD AND STATISTICAL EVALUATION FOR DETERMINING PHARMACOKINETIC PARA-METERS WITH MICROCOMPUTER

In calculating pharmacokinetic parameters, Subjective bias may be induced by using the method of residuals. This paper reports a nonlinear least squares fitting program which may be adapted in APPLE II microcomputer. The program can not only increase the precision of estimated parameters, but also provide objective criteria e.g. Akaike's Information Criterion ( AIC ) for determining which kind of compartment model is most appropriate. Furthermore, the standard error of parameter is calculated which gives the variability of the estimation. The use of this program is guided on-screen prompts that display Some form of menu including the various types of compartmental models for intra and extravascular administration. The data can be stored or drawn out from the disk and the plot of curve fitting is readily feasible.