| 一个新的代谢调节因子——成纤维细胞生长因子21 |
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| 引用本文： | 张谢,王周光,李晓霞,时洪雪,朱小静,李校堃,肖健. 一个新的代谢调节因子——成纤维细胞生长因子21[J]. 药物生物技术, 2011, 0(3): 269-272 |
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| 作者姓名： | 张谢 王周光 李晓霞 时洪雪 朱小静 李校堃 肖健 |
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| 作者单位： | 温州医学院药学院浙江省生物技术制药工程重点实验室; |
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| 摘 要： | 成纤维细胞生长因子21(FGF21)与其传统的FGFs家族不同,是一个新的代谢调节因子,虽然发现时间不长,但在代谢性疾病中的调控机制研究开展十分迅速。FGF21是2型糖尿病的潜在治疗剂,其具有持续控制脂质和糖代谢,逆转胰岛素的耐受性,改善胰岛β细胞等功能。另外,在特定靶组织/器官,很多与代谢相关的关键因子和途径,与FGF21调控机制相关。进一步研究这些作用机制不仅能更好的理解FGF21的生物学特性,还能为研究新的治疗方案奠定基础。文中叙述了糖尿病、肥胖症、肝癌、慢性肾病等疾病与FGF21的调控关系,以及目前FGF21调控机制的研究进展。
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| 关 键 词： | 成纤维细胞生长因子21 糖尿病 肥胖症 代谢调节 |
Fibroblast Growth Factor 21 as a Novel Metabolic Regulator |
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| ZHANG Xie,WANG Zhou-guang,LI Xiao-xia,SHI Hong-xue,ZHU Xiao-jing,LI Xiao-kun,XIAO Jian. Fibroblast Growth Factor 21 as a Novel Metabolic Regulator[J]. Pharmaceutical Biotechnology, 2011, 0(3): 269-272 |
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| Authors: | ZHANG Xie WANG Zhou-guang LI Xiao-xia SHI Hong-xue ZHU Xiao-jing LI Xiao-kun XIAO Jian |
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| Affiliation: | ZHANG Xie1,WANG Zhou-guang1,LI Xiao-xia1,SHI Hong-xue1,ZHU Xiao-jing1,LI Xiao-kun1,XIAO Jian1(1.Wenzhou Medical College,Zhejiang Provincial Key Laboratory of Biotechnical Pharmaceutical Engineering,Wenzhou 325035,China) |
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| Abstract: | Fibroblast growth factor 21(FGF21) is a new metabolic regulator,with several molecular characteristics that differ from classical FGFs,providing a variety of pharmacologic functions that including various metabolic responses in vitro and vivo in animal models.Although FGF21 was discovered relatively recently,the understanding of its biology and therapeutic utility is quickly evolving.FGF21 represents a potent therapeutic agent for obesity and type 2 diabetes,because of its ability to sustain lipid and glouc... |
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| Keywords: | FGF21 Diabetics Obesity Metabolism |
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