| 温敏性聚乙二醇-聚酯类嵌段共聚物研究进展及在生物医药中的应用 |
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| 引用本文： | 蔡晓青,栾玉霞,邵伟. 温敏性聚乙二醇-聚酯类嵌段共聚物研究进展及在生物医药中的应用[J]. 药物生物技术, 2011, 0(3): 260-264 |
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| 作者姓名： | 蔡晓青 栾玉霞 邵伟 |
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| 作者单位： | 山东大学药学院药物制剂研究所; |
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| 摘 要： | 环境敏感水凝胶能随外界环境变化由溶液转变成凝胶,其中温度敏感性水凝胶在不同环境温度刺激下即产生相转变。聚乙二醇-聚酯类嵌段共聚物水溶液室温下是流动的液体,达生理温度时则形成凝胶。该类共聚物有温度敏感性、生物可降解性、生物相容性,可注射性,延长药物的释放时间,作为药物缓释载体被广泛应用于生物医药领域。文章综合国内外文献报道,介绍了聚乙二醇-聚酯类嵌段共聚物的合成、物理凝胶化机理,同时综述了其在生物医药领域中的应用,并对其发展趋势及应用前景作了简单的评述。
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| 关 键 词： | 温敏性 聚乙二醇-聚酯嵌段共聚物 凝胶 生物医药 |
Advances in Thermosensitive Poly(Ethylene Glycol)-Polyester Block Copolymers and its Application in Biomedical Medicine |
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| CAI Xiao-qing,LUAN Yu-xia,SHAO Wei. Advances in Thermosensitive Poly(Ethylene Glycol)-Polyester Block Copolymers and its Application in Biomedical Medicine[J]. Pharmaceutical Biotechnology, 2011, 0(3): 260-264 |
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| Authors: | CAI Xiao-qing LUAN Yu-xia SHAO Wei |
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| Affiliation: | CAI Xiao-qing,LUAN Yu-xia,SHAO Wei(School of Pharmaceutical Science,Shandong University,Jinan 250012,China) |
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| Abstract: | Environmentally responsive hydrogels have the ability to turn from solution to gel when a specific stimulus is applied,and thermoresponsive hydrogels utilize temperature change as the trigger that determines their gelling behavior without any additional external factors.The poly(ethylene glycol)-polyester block copolymer solutions are liquid at a ambient temperature and become gel at physiological temperature.They have been widely used in biomedical fields owing to the characteristics of thermosensitive,bio... |
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| Keywords: | Thermosensitive Polyester-poly(ethylene glycol) Gel Biomedical |
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