| 阿魏酸钠对氧化低密度脂蛋白所致的内皮细胞释放NO的影响 |
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| 引用本文： | 刘梦琼,郑义. 阿魏酸钠对氧化低密度脂蛋白所致的内皮细胞释放NO的影响[J]. 华中医学杂志, 2002, 26(1): 15-16 |
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| 作者姓名： | 刘梦琼 郑义 |
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| 作者单位： | 1. 570311,海口,海南省人民医院检验科
2. 430022,武汉,武汉市第一医院皮肤科 |
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| 摘 要： | 目的：分析阿魏酸钠的抗动脉粥样硬化作用机制，为临床治疗提供理论依据。方法：首先在体外进行低密度脂蛋白的氧化，然后分别与加有不同浓度的阿魏酸钠的人脐静脉内皮细胞（HUVEC）共同孵育，测定培养基上清液中NO的含量，从而观察阿魏酸钠对氧化低密度脂蛋白所致HUVEC释放NO的影响。结果：阿魏酸钠能明显抑制UVEC所致的NO下降作用，这种抑制作用无剂量依赖性。结论：阿魏酸钠的抗动脉粥样硬化作用机制可能通过NO发挥作用。
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| 关 键 词： | 阿魏酸钠 氧化低密度脂蛋白 人脐静脉内皮细胞 一氧化氮 抗动脉粥样硬化作用 |
| 修稿时间： | 2001-08-10 |
Effect of Asafoetida acid sodium on OX-LDL-induced NO release in endoderlial cells. |
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| Liu Mengqiong ,Zheng Yi. Laboratory,The People's Hospital of Hainan Province,Haikou. Effect of Asafoetida acid sodium on OX-LDL-induced NO release in endoderlial cells.[J]. Central China Medical Journal, 2002, 26(1): 15-16 |
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| Authors: | Liu Mengqiong Zheng Yi. Laboratory The People's Hospital of Hainan Province Haikou |
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| Affiliation: | Liu Mengqiong *,Zheng Yi. *Laboratory,The People's Hospital of Hainan Province,Haikou 570311 |
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| Abstract: | Objective To study the mechanism of anti arteriosclerosis of asafoetida acid sodium(SF) so as to provide theory basis for clinical treatment.Methods Low density lipid(LDL) was oxidized in vitro, then coincubated with human umbilical venous endothelial cells(HUVEC) at different concentrations of SF.The levels of NO in the culture supernatant were measured in order to observe the effect of SF on OX LDL induced NO release in HUVEC.Results SF could obviously inhibit the decrease of NO release in HUVEC in no dose dependent manner. Conclusion The decrease of NO release could play a role in the mechanism of SF anti arteriosclerosis. |
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| Keywords: | Asafoetida acid sodium OX LDL HUVEC NO |
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