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Pharmacokinetics and tissue distribution of larotaxel in rats: comparison of larotaxel solution with larotaxel-loaded folate receptor-targeting amphiphilic copolymer-modified liposomes |
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| Authors: | Xue-Feng Lu Yang Zhou Jian Zhang Guo-Qin Wang |
| Affiliation: | 1. Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China,;2. Department of Measurement and Control, School of Physics, Liaoning University, Shenyang, China,;3. Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China, and;4. Department of Mathematics, Liangjiazi Middle School, Shenyang, China |
| Abstract: | 1.?The aim of this study was to compare the pharmacokinetics (PKs) and tissue distribution of larotaxel (LTX) solution with a newly developed formulation called LTX-loaded folate-poly (PEG-cyanoacrylate-co-cholesteryl cyanoacrylate) (FA-PEG-PCHL)-modified liposomes in rats.2.?An ultra-performance liquid chromatography-tandem mass spectrometry method has been developed and validated for the determination of LTX in rat plasma and tissues to investigate the in?uence of FA-PEG-PCHL-modified lipid carrier on LTX PKs and tissue distribution.3.?The PK study result showed significantly higher area under the concentration-time curve (97.2%, **p?p?p?p?p?p?p?p?4.?These results indicated that the FA-PEG-PCHL-modified liposome could be an effective parenteral carrier for the delivery of LTX in cancer treatment. |
| Keywords: | Folate-poly (PEG-cyanoacrylate-co-cholesteryl cyanoacrylate) larotaxel liposomes pharmacokinetics tissue distribution |