| 硝苯吡啶对正常人和充血性心衰病人交感神经系统活性和血浆肾素活性的影响 |
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| 引用本文： | 王志勤,冯清平,张林,陈达光. 硝苯吡啶对正常人和充血性心衰病人交感神经系统活性和血浆肾素活性的影响[J]. 东南大学学报(医学版), 1987, 0(4) |
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| 作者姓名： | 王志勤 冯清平 张林 陈达光 |
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| 作者单位： | 南京铁道医学院内科学教研室，南京铁道医学院内科学教研室，南京铁道医学院内科学教研室，南京铁道医学院内科学教研室 研究生，导师 |
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| 摘 要： | 正常人和心衰病人口服20mg硝苯吡啶后血压均下降,正常人的心率、血浆肾素活性和去甲肾上腺素含量无变化,而心衰病人药后心率减慢,血浆去甲肾上腺素含量降低。正常人和心衰病人硝苯吡啶的药峰浓度和药峰时间无显著差异。研究结果提示口服硝苯吡啶片并不引起交感神经系统和肾素——血管紧张素系统的反射性兴奋。
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| 关 键 词： | 硝苯吡啶 去甲肾上腺素 交感神经系统 血浆肾素活性 充血性心力衰竭 钙拮抗剂 |
THE EFFECT OF NIFEDIPINE ON THE SYMPATHETIC ACTIVITY AND PLASMA RENIN ACTIVITY IN NORMAL SUBJECTS AND PATIENTS WITH CONGESTIVE HEART FAILURE |
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| Wang Zhiqin,Feng Qingping,Zhang Lin,Chen Daguang. THE EFFECT OF NIFEDIPINE ON THE SYMPATHETIC ACTIVITY AND PLASMA RENIN ACTIVITY IN NORMAL SUBJECTS AND PATIENTS WITH CONGESTIVE HEART FAILURE[J]. Journal of Southeast Univ: Medical Sci Ed, 1987, 0(4) |
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| Authors: | Wang Zhiqin Feng Qingping Zhang Lin Chen Daguang |
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| Abstract: | 20-mg nifedipine tablet lowered blood pressure in healthy volunteers and patients with congestive heart failure with heart rate, plasma renin activity and norepinrphrine levels unchanged in normal subjects, and heart rate and plasma norepinephrine concentration decreased in patients. The simultaneous determination of plasma nifedipine showed that there was no difference in the peak concentration and peak time after nifedipine administration between healthy subjects and patients. It is suggested that the vasodilation effect of nifedipine tablet is not accompanied with reflex activation of sympathetic nervous system and the renin-angiotensin system. |
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| Keywords: | nifedipine norepinephrine sympathetic nervous system plasma renin activity congestive heart failure calcium antagonist |
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