| TTF-1和SPA表达对早期肺腺癌术后复发预测及预后的判断价值 |
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| 引用本文： | 刘瑞青,李醒亚,曹会存,李辉,曹广劭,刘建文,吴方明,刘玉岩,刘健,陈利娟.TTF-1和SPA表达对早期肺腺癌术后复发预测及预后的判断价值[J].实用癌症杂志,2017(7). |
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| 作者姓名： | 刘瑞青 李醒亚 曹会存 李辉 曹广劭 刘建文 吴方明 刘玉岩 刘健 陈利娟 |
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| 作者单位： | 1. 河南省人民医院, 郑州大学附属人民医院,450000;2. 450000,郑州大学第一附属医院;3. 450000,河南省肿瘤医院 |
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| 基金项目： | 国家自然科学基金(21504082) |
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| 摘 要： | 目的 研究术后肺腺癌患者组织中TTF-1和SPA的蛋白表达对其复发的预测价值及预后的影响.方法 收集行手术切除的Ⅰ～Ⅲ期肺腺癌患者112例,采用免疫组化方法检测组织中TTF-1以及SPA的表达.结果 68例患者出现复发,TTF-1阳性和阴性表达患者中位DFS分别为41个月和9个月(P =0.013),中位OS分别为65.0和23.0个月(P=0.037),SPA阳性与阴性表达患者中位DFS分别为59.0个月和15.0个月(P=0.018),中位OS分别为68.0个月和35.0个月(P =0.058).结论 早期肺腺癌术后组织中TTF-1和SPA的表达是其复发的有效预测指标,TTF-1阳性表达预后更好.
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| 关 键 词： | 肺腺癌 甲状腺转录因子 表面活性蛋白A 无疾病进展生存期 生存期 |
The Predictive Value of the Expressions of TTF-1 and SPA Protein on the Recurrence and Prognosis of Lung Adenocarinoma after Surgery |
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| Abstract: | Objective To study the predictive value of the expressions of TTF-1 and SPA protein on the recurrence and prognosis of lung adenocarinoma after surgery.Methods 112 cases of stage Ⅰ ～ Ⅲ lung adenocarcinoma were selected.The expressions of TTF-1 and SPA protein in tissues were detected by immunohistochemical detection.Results 68 cases had recurrence,median DFS of patients with positive and negative expression of TTF-1 were respectively 41 months and 9 months (P =0.013),the median OS were 65.0 months and 23.0 months respectively (P =0.037),median DFS of patients with positive and negative expression of SPA were respectively 59.0 months and 15.0 months (P =0.018),the median and OS were respectively 68.0 and 35.0 months (P =0.058).Conclusion The expression of TTF-1 and SPA in postoperative lung adenocarcinoma are effective predictors of recurrence.The patients with positive expression of TTF-1 have better prognosis. |
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| Keywords: | Lung adenocarinoma TTF-1 SPA DFS OS |
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