Ki67、p53及EGFR在胃癌组织中的表达水平及临床意义

目的 探讨Ki67、p53及EGFR在胃癌组织中的表达水平及其临床意义.方法 收取行病理学检查的胃癌患者170例作为研究对象,对其胃癌组织及癌旁组织的石蜡切片进行ki67、p53及EGFR免疫组化染色.结果 胃癌组织中Ki67、p53及EGFR阳性表达率分别为71.18%、55.88%及45.29%;癌旁组织中Ki67、p53及EGFR阳性表达率分别为31.76%、12.94%及10.59%.胃癌组织阳性表达率均明显高于癌旁组织,差异具有统计学意义(P<0.05).3种指标均与肿瘤浸润深度、分化程度、淋巴结转移以及TNM分期密切相关,即随着肿瘤进展而其阳性率增高(P<0.05).Ki67与p53、EGFR均呈正相关(P<0.05);p53与EGFR相关性不显著(P>0.05).结论 Ki67、p53及EGFR与胃癌的发展关系密切,均可作为判断胃癌恶性程度及进展情况的可靠指标.

Expression of Ki67,p53 and EGFR in Gastric Cancer and Clinical Significance

Objective To explore the expression of Ki67,p53 and EGFR in gastric cancer and clinical significance.Methods 170 patients with gastric cancer underwent pathological test in our department from May 2014 to May 2015 were se-lected to this study.The expression of Ki67,p53 and EGFR of tumor tissues and para-carcinoma tissues was detected by immuno-histochemical method.Results Expression rate of Ki67,p53 and EGFR in gastric cancer tissues was respectively 71.18%, 55.88%and 45.29%;in para-carcinoma tissues was respectively 31.76%,12.94% and 10.59%.Expression rate in gastric cancer tissues was obviously higher than para-carcinoma tissues with statistically significance (P<0.05).Positive expression was related to the depth of invasion,degree of differentiation,lymphatic metastasis and TNM stages(P<0.05).Ki67 expression was positively correlated with p53 and EGFR(P<0.05),but correlation between p53 and EGFR had no statistically significance (P>0.05).Conclusion Expression of Ki67,p53 and EGFR has close relation with gastric tumor ,which can be used as reliable inde-xes in judgement of tumor malignancy and development.