术后化疗联合榄香烯与单纯手术治疗对食管癌的干预效果及其与患者外周血淋巴细胞cyclinD1、p16的表达水平变化的关联分析

目的 探讨化疗联合榄香烯与单纯手术治疗对食管癌的干预效果及其与患者外周血淋巴细胞cyclinD1、p16表达水平变化的关联.方法 本研究选取食管癌患者59例,包含单纯手术治疗患者30例(对照组)和术后化疗并且联合使用榄香烯进行治疗的观察组患者29例.比较分析化疗联合榄香烯与单纯手术治疗对食管癌的干预效果,并分析其与患者外周血淋巴细胞cyclinD1、p16的表达水平变化的关联.采用SPSS 17.0统计学软件进行分析.结果 随访比较2组患者治疗后2年的疗效情况,观察组无病生存时间为(12.58±7.12)月,中位无病生存时间为13.5个月,均略高于对照组.2组患者治疗前的cyclinD1水平及p16水平均未见差别;治疗后2组的cyclinD1水平分别为(2.43±1.42)、(4.03±1.54),p16水平分别为(6.95±2.75)、(5.02±2.55),组间均存在统计学差异(P＜0.01).结论 手术干预对于集体细胞周期蛋白组的调控会产生一定影响,cyclinD1与p16的双向下调有可能提示术后肿瘤的复发与转移.同时榄香烯干预会影响cyclinD1加速下调,p16下调则会受到相对抑制,可能对于控制术后复发转移有一定的功效.

A Comparison of the Effect of Chemotherapy Combined with Elemene and Simple Surgery on Esophageal Cancer and the Relative Association with the Expression of CyclinD1 and p16 in Peripheral Blood Lymphocytes

Objective To investigate the effect of chemotherapy combined with elemene and simple surgery on esophageal cancer and the correlation with the expression of cyclinD1 and p16 in peripheral blood lymphocytes.Methods 59 patients with esophageal cancer who had been diagnosed with esophageal cancer were enrolled in this study.30 patients who underwent surgery alone and postoperative chemotherapy were treated with elemene.Comparative analysis of the effect of combined chemotherapy with elemene and simple surgery on esophageal cancer and the correlation with the expression of cyclinD1 and p16 in peripheral blood lymphocytes.SPSS17.0 statistical software was used for analysis.Results The mean value of disease-free survival time was (12.58±7.12)months,and the median disease-free survival time was 13.5 months,which were slightly higher than those in the control group.The levels of cyclinD1 were (7.58±1.12)and (7.53±1.03),respectively,and the levels of p16 were (8.30±2.33)and (8.45±2.54)respectively.There was no difference between the 2 groups.The levels of cyclinD1 were (2.43±1.42)and (4.03±1.54),respectively.The levels of p16 were (6.95±2.75)and (5.02±2.55),respectively.There was significant difference between the 2 groups(P＜0.01).Conclusion Surgical intervention may play an important role in the regulation of the cell cycle protein group.The two-way down-regulation of cyclinD1 and p16 may suggest the development of postoperative tumor.At the same time elemene intervention will affect the cyclinD1 accelerated down,p16 down will receive a relative inhibition,may be for the control of postoperative recurrence and metastasis have a certain effect.