| miRNA调控肿瘤多药耐药的研究进展 |
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| 引用本文： | 安艳新,赵青川.miRNA调控肿瘤多药耐药的研究进展[J].现代肿瘤医学,2017(17):2848-2851. |
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| 作者姓名： | 安艳新 赵青川 |
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| 作者单位： | 1. 济南军区总医院普通外科,山东 济南,250031;2. 第四军医大学西京消化病医院,陕西 西安,710032 |
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| 基金项目： | 国家自然科学基金(81602651)，济南军区总医院院长基金(2015BS04) |
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| 摘 要： | 耐药导致肿瘤化疗失败的分子机制至今尚未完全阐明.多项研究发现miRNA广泛参与了肿瘤增殖、转移、凋亡等多个生物学过程.近年来研究证实,miRNA在多种肿瘤耐药过程中发挥重要调节作用.通过阅读文献,本文旨在汇总miRNA调控肿瘤耐药的分子机制.
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| 关 键 词： | miRNA 多药耐药 分子机制 |
Research advances of miRNA in regulating multidrug resistance of tumor |
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| An Yanxin,Zhao Qingchuan.Research advances of miRNA in regulating multidrug resistance of tumor[J].Journal of Modern Oncology,2017(17):2848-2851. |
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| Authors: | An Yanxin Zhao Qingchuan |
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| Abstract: | Drug resistance leads to the failure of chemotherapy and its molecular mechanism has not been fully elucidated.A number of studies have found that miRNA is involved in many biological processes of tumor,such as proliferation,metastasis,apoptosis and so on.In recent years,it has been confirmed that miRNA also plays an important role in regulating multidrug resistance of tumor.This paper aims to summarize the molecular mechanisms of miRNA in regulating multidrug resistance of tumor. |
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| Keywords: | miRNA multidrug resistance molecular mechanism |
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