聚乙烯醇栓塞微球可载药微球介入治疗中晚期肝癌的临床疗效及安全性观察

目的 探究聚乙烯醇可载药栓塞微球介入治疗中晚期肝癌的临床疗效及安全性.方法 将60例中晚期肝细胞癌患者,根据患者的疾病实际情况和患者的意愿结合,随机分为对照组,治疗组和实验组,每组20例.对照组采用传统的单纯碘化油乳剂栓塞TACE术,治疗组采用碘化油乳剂+明胶海绵栓塞TACE术,实验组采用碘化油乳剂+Callispheres可载药微球栓塞TACE术,对比3组患者TACE术后的不良反应、1个月后的肿瘤坏死率和术前、术后AFP变化.结果 实验组和对照组术后不良反应较少,均少于治疗组;实验组和治疗组术后1月肿瘤坏死率明显高于对照组,实验组与治疗组术后1月肿瘤坏死率相当;3组患者的术后AFP水平均明显低于术前.结论 应用聚乙烯醇可载药栓塞微球+碘油对中晚期肝癌患者行TACE术,比传统的应用碘化油的TACE术,手术效果好;比明胶海绵+碘化油的TA-CE术,手术效果相当,但是其导致的并发症较少,更利于患者术后恢复.

Clinical Efficacy and Safety of Polyvinyl Alcohol Callispheres in the Interventional Therapy for Advanced Liver Cancer

Objective To investigate the clinical efficacy and safety of polyvinyl alcohol callispheres in the intervention-al therapy for advanced liver cancer. Methods 60 patients diagnosed with advanced hepatocellular carcinoma were randomly di-vided into the control group,the treatment group and the experimental group;each with 20 cases. The control group received tradi-tional TACE surgery with lipiodol;the treatment group received lipiodol+gelatin sponge embolization,and the experimental group received callispheres microspheres+lipiodol. Compared the AFP changes before and after TACE surgery,adverse reactions and the tumor necrosis rate after TACE of the 3 groups. Results The experimental group and the control group had less adverse reac-tions than the treatment group;the experimental group and the treatment group had significantly higher tumor necrosis rate 1 month after TACE surgery than the control group,and the experimental group has the same tumor necrosis rate 1 month after TACE sur-gery as the treatment group. The AFP level of the 3 groups after TACE was significantly lower than that before TACE. Conclusion The application of callispheres+lipiodol in TACE has the same clinical efficacy as gelatin sponge+lipiodol,but has better effica-cy than the traditional treatment with lipiodol. Callispheres+lipiodol has less complications,and it is beneficial for the recovery of patients after TACE.