三阴性乳腺癌中MMP-9的表达及意义

目的:探讨三阴性乳腺癌(TNBC)中基质金属蛋白酶-9(MMP-9)的表达及意义.方法:收集2012年1月至2013年12月乳腺浸润性导管癌共158例,应用免疫组织化学及荧光原位杂交技术将乳腺癌分为65例TNBC、93例非TNBC.免疫组织化学检测MMP-9的表达情况,明确MMP-9在二组间表达的区别.分析MMP-9在TNBC中与临床病理特征关系,并随访65例TNBC患者3年复发或转移率,探讨MMP-9表达与3年复发转移率间的关系.结果:TNBC中MMP-9表达明显高于非TNBC(P<0.05);TNBC中MMP-9表达与年龄和肿瘤大小无关(P>0.05),与TNM分期、组织学分级、淋巴结状态及脉管浸润有关,差异具有统计学意义(P<0.05);MMP-9阳性的TNBC患者3年复发转移率高达76.09%,明显高于MMP-9阴性组47.37%,差异具有统计学意义(P<0.05).结论:TNBC中MMP-9表达明显高于非TNBC,MMP-9与TNBC浸润转移有关,对预测3年复发转移有明显意义.

The expression and significance of MMP-9 in triple negative breast cancer

Objective:To investigate the expression and significance of MMP-9 in triple negative breast cancer (TNBC).Methods:158 cases of breast invasive ductal carcinoma in our hospital were retrospectively analyzed.Ac-cording to the expression of ER,PR,HER-2,we categorized those paitent into triple negative breast cancer group (65 cases)and non triple negative breast cancer (93 cases).The different expression of MMP-9 was detected by immunohistochemieal technology in two groups.We analyzed the relationship between the expression of MMP-9 and clinical and pathological features in TNBC,and investigated the effect of MMP-9 on the rate of recurrence and me-tastasis in 3 years.Results:The expression of MMP-9 in TNBC was significantly higher than that of no-TNBC (P< 0.05).The expression of MMP-9 in TNBC was associated with TNM stage,histological grade,lymph node status and vascular invasion(P< 0.05),but not with age and size of the tumor (P > 0.05).The rate of recurrence and me-tastasis in positive expression of MMP-9 in TNBC was 76.09%,which was significantly higher than negative expres-sion of MMP-9 in TNBC (47.37%),and the statistically significant was found (P< 0.05).Conclusion:The ex-pression of MMP-9 in TNBC was significantly higher than that of no-TNBC,and its expression is associated with the rate of recurrence and metastasis in 3 years.