尼妥珠单抗联合调强放疗及周期化疗治疗局部晚期宫颈癌的临床观察

目的 探讨尼妥珠单抗联合调强放疗及周期化疗在局部晚期宫颈癌的治疗中的临床效果.方法 将80例局部晚期宫颈癌患者分为对照组和观察组.观察组患者43例,行尼妥珠单抗联合调强放疗及周期化疗治疗;对照组患者37例,行调强放疗及周期化疗.比较2组患者的临床有效率、肿瘤体积退缩情况、不良反应发生率以及局部复发和远处转移.结果 在放疗结束后3个月,宫颈癌患者治疗的总有效率观察组和对照组分别为88.4%和70.3%,观察组显著高于对照组(P<0.05);在治疗后2周,观察组患者的肿瘤体积显著小于对照组(P<0.05);在治疗后4周,2组患者肿瘤体积存在显著统计学差异(P<0.05).2组患者在治疗后1年内均有远处转移和局部复发情况发生,其中观察组患者的局部复发和远处转移发生情况显著低于对照组(P<0.05).2组患者不良反应发生情况不存在统计学差异(P>0.05).结论 尼妥珠单抗联合调强放疗及周期化疗能够显著提高局部晚期宫颈癌患者的近期疗效,快速退缩肿瘤体积,降低患者的复发率和远处转移率.

Clinical Observation of Nimotuzumab Combined with Intensity Modulated Radiation Therapy ( IMRT) and Cycles of Chemotherapy for Locally Advanced Cervical Cancer

Objective To study the clinical efficacy of nimotuzumab combined with intensity modulated radiation therapy ( IMRT) and cycles of chemotherapy for locally advanced cervical cancer .Methods 80 patients with locally advanced cervical cancer,were divided into the control group and the observation group;43 patients in the observation group received nimotuzumab combined with IMRT and cycles of chemotherapy ,37 patients in the control group received IMRT and cycles of chemotherapy . Clinical efficiency ,tumor size shrinking situation ,the incidence of adverse reactions ,local recurrence and distant metastasis of the 2 groups were compared .Results 3 months after radiotherapy , the total effective rate of the observation group and the control group patients were 88.4%and 70.3%,respectively,the observation group was significantly higher than the control group (P<0.05);2 weeks after treatment ,tumor size of the observation group was significantly smaller than the control group ( P<0.05);4 weeks after treatment ,there had no significant difference in tumor size between the 2 groups ( P>0.05);Within 1 year after treatment,both groups had distant metastasis and local recurrence ,and distant metastasis and local recurrence of the observation group were significantly lower than the control group ( P<0.05);Adverse reactions between the 2 groups had no significant difference (P>0.05).Conclusion Nimotuzumab combined with IMRT and cycles of chemotherapy can significantly improve short-term curative effect of locally advanced cervical cancer ,quickly reduce tumor volume ,recurrence and distant metastasis .