| 子宫内膜癌组织中DcR3的表达及临床意义 |
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| 引用本文： | 肇丽杰,郑玉华,牛菊敏,陈永连,陈向东.子宫内膜癌组织中DcR3的表达及临床意义[J].现代肿瘤医学,2017(17):2785-2788. |
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| 作者姓名： | 肇丽杰 郑玉华 牛菊敏 陈永连 陈向东 |
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| 作者单位： | 1. 佛山市妇幼保健院妇科,广东 佛山,528000;2. 沈阳市妇婴医院妇科,辽宁 沈阳,110014 |
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| 基金项目： | 佛山市科技局科研课题(2014AB00379) |
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| 摘 要： | 目的:检测DcR3在正常增生期子宫内膜、子宫内膜非典型增生和子宫内膜癌组织中的表达,探讨它们在子宫内膜癌发生、发展中的作用.方法:用免疫组织化学法检测DcR3在不同子宫内膜组织中的表达情况.结果:DcR3在子宫内膜癌组织中的表达水平均高于子宫内膜非典型增生和增生期子宫内膜组织(P<0.01).DcR3的表达与子宫内膜癌的临床分期和有无淋巴结转移有关(P<0.05),但与不同病理类型、组织学分级无关(P>0.05).结论:DcR3 在子宫内膜癌的发生、发展过程中可能起着重要的作用.
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| 关 键 词： | 子宫内膜癌 免疫组化 DcR3 |
Expression and clinical significance of DcR3 in human endometrial carcinoma tissues |
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| Zhao Lijie,Zheng Yuhua,Niu Jumin,Chen Yonglian,Chen Xiangdong.Expression and clinical significance of DcR3 in human endometrial carcinoma tissues[J].Journal of Modern Oncology,2017(17):2785-2788. |
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| Authors: | Zhao Lijie Zheng Yuhua Niu Jumin Chen Yonglian Chen Xiangdong |
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| Abstract: | Objective:To detect the expressions of DcR3 protein in the tissue of proliferative phase endometrium、endometrial atypical hyperplasia and endometrial carcinoma,and to explore its clinical significance in the development of endometrial carcinoma.Methods:Immunohistochemistry was performed to detect the expressions of DcR3 in different endometrial tissue.Results:The expression level of DcR3 protein in endometrial carcinoma was significantly higher than that in proliferative phase endometrium and endometrial atypical hyperplasia(P<0.01).The expression of DcR3 was related to the clinical stages and lymph node metastasis of endometrial carcinoma(P<0.05),but not correlated with pathological type and pathological grade of endometrial carcinoma(P>0.05).Conclusion:DcR3 maybe plays a important role in the tumorigenesis and progress of endometrial carcinoma. |
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| Keywords: | endometrial carcinoma immunohistochemistry DcR3 |
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