| 泛素连接酶cbl家族蛋白调控死亡受体信号通路的研究进展 |
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| 引用本文： | 郭天舒,徐玲,刘云鹏. 泛素连接酶cbl家族蛋白调控死亡受体信号通路的研究进展[J]. 现代肿瘤医学, 2017, 0(21): 3523-3527. DOI: 10.3969/j.issn.1672-4992.2017.21.039 |
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| 作者姓名： | 郭天舒 徐玲 刘云鹏 |
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| 作者单位： | 中国医科大学附属第一医院肿瘤内科,辽宁沈阳,110001 |
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| 基金项目： | 国家自然科学基金项目(81673025)，辽宁省自然科学基金项目(2014021069) |
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| 摘 要： | 死亡受体信号通路是引起细胞凋亡,维持细胞稳态的重要途径,对监视机体肿瘤具有重要意义.死亡受体通路主要包括三条:TNFα及其受体途径,FasL/Fas途径,TARIL及其受体DR4/5途径.近年来,关于cbl家族蛋白调控死亡受体通路的研究越来越多.cbl家族蛋白作为泛素连接酶Ring-finger结构域家族的重要成员之一,通过调节蛋白的泛素化,参与体内的多种生理过程.本文就死亡受体、脂筏、生存通路及其它分子四个方面,综述cbl家族蛋白调控死亡受体信号通路的研究进展.
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| 关 键 词： | cbl 死亡受体 TRAIL TNFα Fas 脂筏 |
Advances on ubiquitin ligase cbl family protein regulating death receptor signaling pathway |
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| Guo Tianshu,Xu Ling,Liu Yunpeng. Advances on ubiquitin ligase cbl family protein regulating death receptor signaling pathway[J]. Journal of Modern Oncology, 2017, 0(21): 3523-3527. DOI: 10.3969/j.issn.1672-4992.2017.21.039 |
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| Authors: | Guo Tianshu Xu Ling Liu Yunpeng |
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| Abstract: | Death receptor signaling pathway is important to induce cell apoptosis and maintain cell homeostasis.It is significant to monitor tumor initiation.The death receptor pathway mainly includes:TNFα and its receptor pathway,FasL/Fas pathway,TARIL and its receptor DR4/5 pathway.In recent years,there are many studies about the regulation of cbl family protein on death receptor pathway.Cbl family protein is the important members of the ring-finger domain family of ubiquitin ligase.It is involved in a variety of physiological processes through regulating protein ubiquitination.In this paper,we review the progress of cbl family protein regulating death receptor signaling pathway about death receptor,lipid raft,survival pathway and other molecules. |
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| Keywords: | cbl death receptor TRAIL TNFα Fas lipid raft |
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