结直肠癌肝转移患者经微波消融联合肝动脉栓塞化疗的效果和肝功能变化情况

目的探讨微波消融术(MWA)联合肝动脉化疗栓塞术(TACE)治疗结直肠癌肝转移中的临床疗效及其患者肝功能变化、生存情况以及生活质量评价。方法回顾性分析80例结直肠癌肝转移患者的临床相关资料,其中有38例单独行肝动脉化疗栓塞术治疗,为TACE组;其他42例行微波消融联合肝动脉栓塞化疗进行治疗,为MWA+TACE组。对2组的临床疗效、患者肝功能变化、生存情况以及生活质量评价数据进行整理分析。结果 TACE组和MWA+TACE组的临床有效率分别是39.5%和76.2%,MWA+TACE组患者的临床疗效显著优于TACE组患者(χ~2=11.098,P≈0.001)。2组患者的血清白蛋白、谷丙转氨酶、总胆红素含量等肝功能各项指标不存在统计学差异(P>0.05)。MWA+TACE组患者的2年、3年生存率显著高于TACE组(P<0.05)。在治疗6个月后,MWA+TACE组患者的生理状况、功能状况、情感状况、家庭/社会状况均显著高于TACE组患者(P<0.05);在总体评分上,MWA+TACE组患者显著优于TACE组(P<0.05)。结论微波消融联合肝动脉栓塞化疗治疗结肠癌肝转移有非常显著的效果,相对于单独化疗,能够延长患者的生存时间以及提高其生活质量,且对肝功能不会造成损害。

Efficacy of Microwave Ablation Combined with Transcatheter Arterial Chemoemboliza-tion for Liver Metastases of Colorectal Cancer and Changes in Liver Function

Objective To investigate the clinical efficacy of microwave ablation ( MWA) combined with transcatheter ar-terial chemoembolization ( TACE) in the treatment of liver metastases of colorectal cancer ,and changes in liver function ,evaluation of survival and quality of life .Methods A retrospective analysis of clinical data of 80 cases of colorectal cancer patients with liv-er metastases were conducted ,38 cases received only hepatic artery chemoembolization therapy was TACE group ,42 cases re-ceived routine microwave ablation combined with transcatheter arterial chemoembolization treatment was MWA +TACE group. Clinical efficacy,liver function,survival and quality of life evaluation data of the 2 groups were analyzed.Results Clinical effec-tive rates of TACE group and MWA +TACE group were 39.5%and 76.2%,clinical efficacy of MWA +TACE group were sig-nificantly better than the TACE group(χ2 =11.098,P≈0.001).Serum albumin,alanine aminotransferase,total bilirubin levels and other indicators of liver function between the 2 groups had no significant difference ( P>0.05);2-,3-year survival rates of MWA +TACE group were significantly higher than TACE group (P<0.05);after 6 months of treatment,physiological condition, functional status ,emotional status ,family/social conditions of MWA +TACE group were significantly higher than TACE group ( P<0.05),in the overall score,MWA +TACE group were significantly better than TACE group (P<0.05).Conclusion Micro-wave ablation combined with transcatheter arterial embolization chemotherapy for colon cancer with liver metastasis has significant effect,compared with chemotherapy alone ,it can prolong the survival time of patients and improve their quality of life ,and will not cause damage to liver function .