Maspin和Ki67在子宫内膜癌中的表达及其相关性分析

目的:探讨在正常子宫内膜、子宫内膜增殖症(非典型)和子宫内膜癌中Maspin和Ki67的表达、相关性及与临床病理特征的关系.方法:采用免疫组织化学方法检测Maspin和Ki67在30例正常增生期子宫内膜、40例子宫内膜增殖症(非典型)和72例子宫内膜癌中的表达.结果:在子宫内膜癌中,Ki67表达分别显著高于正常子宫内膜和子宫内膜增殖症(P =0.043;P =0.020),Maspin表达分别显著高于正常子宫内膜和子宫内膜增殖症(P ＜0.05);Ki67与子宫内膜癌的组织学分级和分期有统计学差异(P＜0.05),Maspin与子宫内膜癌的组织学分级、分期和淋巴结转移有统计学差异(P＜0.05),Maspin和Ki67表达呈正相关(r=0.231,P =0.005).结论:在子宫内膜癌中,Maspin和Ki67的表达提示两者可能成为子宫内膜癌的预后因子.

Expression and their correlation of Maspin and Ki67 in endometrial carcinoma

Objective:To investigate the expression of Maspin and Ki67,their relationship with the pathological clinical features of normal endometrial tissue,endometrial hyperplasia (atypical) and human endometrial carcinoma.Methods:30 normal endometrial tissues,40 cases of endometrial hyperplasia(atypical) and 72 endometrial carcinomas were collected.Immunohistochemistrical methods were used to detect their Maspin and Ki67 expression.Results:In endometrial carcinomas,the expression of Ki67 was significantly higher than that of normal and endometrial hyperplasia (P =0.043;P =0.020),and the expression of Maspin was significantly higher than that of normal and endometrial hyperplasia.The expression of Ki67 was significantly different in tumor grade and staging respectively(P ＜ 0.05).The expression of Maspin was significantly different in histology grade,FIGO stage and lymph node metastasis respectively(P ＜0.05).There was positive correlation between the expression of Maspin protein and that of Ki67 (r =0.231,P =0.005).Conclusion:These results showed possibie role of expression of Maspin and Ki67 as prognostic factor in endometrial carcinoma.