立体定向靶向微创手术联合125 I粒子植入术治疗脑胶质瘤的临床效果

目的 探讨立体定向靶向微创手术联合125 I粒子植入术治疗脑胶质瘤的临床效果.方法 选择78例脑胶质瘤患者作为研究对象,采用随机信封抽签原则分为观察组与对照组,各39例.对照组给予立体定向靶向微创手术治疗,观察组在对照组治疗的基础上给予125I粒子植入术治疗.结果 观察组的总有效率明显高于对照组(P<0.05).观察组术后28 d内的发热、局部疼痛、水肿、恶心呕吐等并发症发生率为10.3%(4/39),对照组为43.6%(17/39),观察组明显低于对照组(P<0.05);术后28 d,2组的KPS与ECOG评分与术前对比,差异均有统计学意义(P<0.05);术后28 d观察组KPS、ECOG评分明显优于对照组(P<0.05).随访至今,观察组与对照组的中位生存时间分别为(30.94±2.48)个月和(21.44±3.19)个月,观察组明显好于对照组(P<0.05).结论 立体定向靶向微创手术联合125I粒子植入术治疗脑胶质瘤能提高治疗效果,减少术后并发症,改善临床症状,延长患者的生存时间.

Clinical Efficacy of Stereotactic Minimally Invasive Surgery Combined with 125 I Particle Implantation in the Treatment of Brain Glioma

Objective To investigate the clinical efficacy of stereotactic minimally invasive surgery combined with 125 I particle implantation in the treatment of brain glioma. Methods 78 cases of glioma patients were randomly divided into the ob-servation group and the control group,each with 39 cases. The control group received stereotactic minimally invasive surgery,the observation group was given stereotactic minimally invasive surgery combined with 125 I particle implantation. Results The total effective rate of the observation group was significantly higher than that of the control group (P<0. 05). 28 days after surgery,in-cidence of fever,local pain,edema,nausea and vomiting in the observation group was 10. 3%(4/39)which was significantly lower than the control group was 43. 6%(17/39) (P<0. 05). 28 days after surgery,the difference of the KPS and ECOG score in the 2 groups was statistically significant compared with preoperative(P<0. 05). The KPS and ECOG scores in the observation group were significantly better than those in the control group (P<0. 05). The median survival time of the observation group and the control group were (30. 94 ± 2. 48)months and (21. 44 ± 3. 19) months respectively,and the observation group was significantly better than the control group (P<0. 05). Conclusion Stereotactic minimally invasive surgery combined with 125I particle im-plantation in the treatment of brain glioma can improve the therapeutic effect,reduce the incidence of postoperative complications, improve the patient's clinical symptoms,and prolong the survival time of patients.