舒芬太尼复合丙泊酚靶控输注对肺癌根治术患者的麻醉效果及安全性

目的 观察舒芬太尼复合丙泊酚靶控输注对肺癌根治术患者的麻醉效果以及安全性.方法 纳入70例行肺癌根治术的患者,根据给药方式不同分为两组各35例.研究组给予舒芬太尼复合丙泊酚靶控输注,对照组给予舒芬太尼静脉恒速注射配合丙泊酚靶控输注.观察:两组患者麻醉诱导期前后收缩压(SBP)、舒张压(DBP)、心率(HR)等变化;两组患者术后呼吸恢复时间、拔管时间以及睁眼时间;两组患者停止给药后意识程度(OAA/S评分).结果 两组患者麻醉诱导后SBP、DBP、HR水平均较诱导前显著下降(P＜0.05).研究组诱导后SBP、DBP、HR分别为(98.4±10.1)mmHg、(59.1±9.2) mmHg、(82.5±5.4)次/分,对照组分别为(103.0±10.9) mmHg、(63.8±8.7) mmHg、(86.3±5.2)次/分,差异均有显著性(P＜0.05);两组患者术后呼吸恢复时间差异无显著性(P＞0.05).研究组拔管时间、睁眼时间分别为(11.24±4.25) min、(10.87±4.45) min,对照组分别为(15.44±4.40) min、(15.76±4.61) min,差异均有显著性(P＜0.05);两组患者停止给药时、停药30 min、停药60 min OAA/S评分差异均无显著性.结论 舒芬太尼复合丙泊酚靶控输注,能够显著改善患者血流动力情况,促进麻醉后恢复,缩短拔管及睁眼时间,降低感染、刺激呼吸道等危险.

Anesthesia Effect and Safety of Sufentanil and Propofol Target Control Infusion for Lung Cancer Patients Treated with Radical Treatment

Objective To observe the anesthesia effect and safety of sufentanil and propofol target control infusion for lung cancer patients treated with radical treatment.Methods 70 cases of lung cancer patients treated with radical treatment were selected and divided into the research group and the control group according to different administration methods.The research group received sufentanil and propofol target control infusion,while the control group received sufentanil intravenous constant speed injection with propofol target control infusion.The change of SBP,DBP,and HR of both groups before and after anesthesia induction period were observed;postoperative breathing recovery time,extubation time,and eye open time of both groups were observed;and OAA/S score after stopping medication of both groups were observed.Results (1) The SBP,DBP,and HR level of both groups after anesthesia induction period were significantly decreased than before (P ＜ 0.05).After induction,the SBP,DBP,and HR score of the research group were (98.4 ± 10.1 mmHg,(59.1 ± 9.2) mmHg,and (82.5 ± 5.4) times/min,while (103.0 ± 10.9) mmHg,(63.8 ± 8.7) mmHg,and (86.3 ± 5.2) times/min in the control group.The differences were significant (P ＜ 0.05);(2) There was no significant different in postoperative breathing recovery time between the 2 groups (P ＞0.05).The extubation time and open time of the research group were (11.24 ± 4.25) min and (10.87 ± 4.45) min,while (15.44 ± 4.40) min and (15.76 ± 4.61) min in the control group.The differences were significant (P ＜ 0.05);(3) There were no significant differences in OAA/S scores at the time of withdrawal,30 min and 60 min after withdrawal (P ＞ 0.05).Conclusion Sufentanil and propofol target control infusion can significantly improve the hemodynamics of patients after anesthesia induction and significantly shorten postoperative extubation time and open time.It is beneficial to recovery,while reducing the risks of infection and respiratory stimulation.