| 长链非编码RNA CCAL在肝癌中的表达及其对预后的影响 |
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| 引用本文： | 王雅玮,杨野,刘宇,王欣,李铁民,石悦. 长链非编码RNA CCAL在肝癌中的表达及其对预后的影响[J]. 现代肿瘤医学, 2017, 0(17): 2774-2778. DOI: 10.3969/j.issn.1672-4992.2017.17.022 |
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| 作者姓名： | 王雅玮 杨野 刘宇 王欣 李铁民 石悦 |
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| 作者单位： | 中国医科大学附属第一医院老年外科,辽宁 沈阳,110001 |
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| 摘 要： | 目的:检测LncRNA-CCAL在肝细胞癌(HCC)中的表达水平,并分析其与肝癌患者临床病理因素及预后的关系.方法:运用RT-PCR技术检测37例肝癌新鲜组织中CCAL的表达水平;运用原位杂交技术(ISH)检测120例肝癌患者组织切片中CCAL的表达水平,并运用卡方检验、COX回归模型、Kaplan-Meier生存曲线分析CCAL表达水平与肝癌患者临床病理因素及预后的关系.结果:37例肝癌新鲜组织标本中29例高表达,且癌组织中平均表达水平明显高于癌旁组织;120例肝癌患者组织切片中85例高表达,其表达水平与肝癌TMN分期和是否转移相关,而且CCAL较高表达的患者预后也相对较差,总生存率明显低于CCAL低表达的患者.结论:CCAL在肝细胞癌中高表达,是肝癌患者预后的独立影响因子.
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| 关 键 词： | 肝细胞癌 RT-PCR 原位杂交 CCAL 预后 |
LncRNA-CCAL is highly expressed in hepatocellular carcinoma and predicts poor prognosis |
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| Wang Yawei,Yang Ye,Liu Yu,Wang Xin,Li Tiemin,Shi Yue. LncRNA-CCAL is highly expressed in hepatocellular carcinoma and predicts poor prognosis[J]. Journal of Modern Oncology, 2017, 0(17): 2774-2778. DOI: 10.3969/j.issn.1672-4992.2017.17.022 |
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| Authors: | Wang Yawei Yang Ye Liu Yu Wang Xin Li Tiemin Shi Yue |
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| Abstract: | Objective:To test the expression of LncRNA-CCAL in hepatoccllular cancer (HCC) and study its influence on HCC prognosis.Methods:Use RT-PCR and in situ hybridization(ISH) were used as test the expression level of CCAL in HCC.Chi-square test,COX regression,Kaplan-Meier survival curve were used as analyze the relationship between CCAL and prognosis.Results:RT-PCR and ISH both showed CCAL was overexpressed in HCC;CCAL expression was related with tumor metastasis,TNM stage and poor prognosis in HCC.Conclusion:LncRNA-CCAL overexpression may be useful as an independent prognostic biomarker for HCC prognosis. |
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| Keywords: | HCC RT-PCR ISH CCAL prognosis |
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