Voice reactions to histamine inhalation in asthma |
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Authors: | L Leinonen H Poppius |
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Institution: | Neural Networks Research Centre, Helsinki University of Technology, Espoo, Finland;Department of Medicine, Division for Respiratory Medicine, Helsinki University Central Hospital, Helsinki, Finland |
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Abstract: | Susceptibility to voice reactions during a histamine provocation test was studied in 21 asthmatics and 21 healthy subjects. Speech samples were recorded before, and 5 and 15 min after histamine inhalation, and the samples were rated by six speech pathologists. Deterioration of voice quality occurred in 2/12 asthmatic men and in 3/9 asthmatic women within 5 min after histamine inhalation; no change was observed between 5 and 15 min. Voice reactions were not related to the degree of bronchial obstruction: the subjects with the most pronounced decrease in peak expiratory flow (PEF) (60–61% in three subjects) did not develop voice reactions, and PEF did not decrease in one subject with voice reactions. No voice reactions were observed in the healthy subjects. |
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Keywords: | asthma histamine provocation test voice disorders |
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