Pharmacokinetics of fluorouracil by intravenous or intraarterial injection |
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Authors: | Geng Baoqin Zhu Yonglian |
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Institution: | (1) Department of Pharmacology, Zhejiang Medical University, Hangzhou |
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Abstract: | High-performance liquid chromatographic (HPLC) analysis of fluorouracil (5-FU) content of the blood and colon of rabbits is
described. There was no marked difference in the plasma 5-FU level and blood concentration time curve following intravenous
(I.V.) (ear vein) or intraarterial (I.A.) (inferior mesenteric artery) injection of 5-FU 15 mg/kg. However, the distribution
of 5-FU in the colon after I.A. administration was quite different that after I.V. administration. At 10, 20 and 30 minutes,
the 5-FU content in the colon was shown to be 31-, 17- and 14-fold higher with I.A. than with I.V.. Colonic tissue AUC0–480 min. was 2453 and 690 min/mg/ml respectively (p<0.05). It is suggested that to inject 5-FU into selected arteries to treat
advanced colorectal cancer may be more useful than I.V. administration. |
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Keywords: | |
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