Modulators and inhibitors of gamma- and beta-secretases |
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Authors: | Schmidt Boris Baumann Stefanie Narlawar Rajeshwar Braun Hannes A Larbig Gregor |
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Institution: | Clemens Sch?pf Institute for Organic Chemistry and Biochemistry, TU Darmstadt, Darmstadt, Germany. Schmidt_Boris@t-online.de |
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Abstract: | Most gene mutations associated with Alzheimer's disease point to the metabolism of amyloid precursor protein as a potential cause. The beta- and gamma-secretases are two executioners of amyloid precursor protein processing resulting in amyloid-beta. Significant progress has been made in the selective inhibition of both proteases, regardless of structural information for gamma-secretase. Several peptidic and nonpeptidic leads were identified for both targets. |
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