Outcome following corpus callosotomy |
| |
| Institution: | 1. Department of Pediatrics, Université de Montréal, Hôpital Ste-Justine, Montréal Canada;2. Department of Neurology, Harvard Medical School, Children’s Hsopital, Boston MassachusettsUSA;1. Brno Epilepsy Center, Department of Child Neurology, Brno University Hospital and Faculty of Medicine, Masaryk University, ?ernopolní 9, Brno 625 00, Czech Republic;2. Brno Epilepsy Center, First Department of Neurology, St. Anne''s University Hospital and Faculty of Medicine, Masaryk University, Peka?ská 53, Brno 656 91, Czech Republic;3. Brno Epilepsy Center, Department of Neurosurgery, St. Anne''s University Hospital and Faculty of Medicine, Masaryk University, Peka?ská 53, Brno 656 91, Czech Republic;4. Central European Institute of Technology (CEITEC), Masaryk University, Kamenice 753/5, Brno 625 00, Czech Republic;1. Division of Neurology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA;2. Department of Radiology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA;3. Division of Pediatric Neurosurgery, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA;1. Department of Pediatrics, Haeundae Paik Hospital, Inje University College of Medicine, Pusan, Republic of Korea;2. Division of Pediatric Neurology, Department of Pediatrics, Epilepsy Research Institute, Severance Children''s Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea;1. Department of Child Neurology, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, 430-8558, Japan;2. Epilepsy and Neurosurgery, Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, 430-8558, Japan;3. Department of Clinical Neurophysiology, Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, 430-8558, Japan;4. Department of General Internal Medicine, Seirei-Hamamatsu General Hospital, Hamamatsu, Shizuoka, 430-8558, Japan;1. Hôpital Henri Gastaut, Marseille, France;2. Service de Pédiatrie, Clocheville Hospital, CHRU Tours F-37000, France;3. Service de Neurochirurgie Pédiatrique, Assistance Publique des Hôpitaux de Marseille, Marseille F-13005, France;4. Service de Neurochirurgie fonctionnelle et Stéréotaxie, Assistance Publique des Hôpitaux de Marseille, Marseille F-13005, France;5. Service de Neuropédiatrie, Assistance Publique des Hôpitaux de Marseille, Marseille F-13005, France;6. Service de Neurophysiologie Clinique, Assistance Publique des Hôpitaux de Marseille, Marseille F-13005, France |
| |
| Abstract: | Although corpus callosotomy has been performed since 1940 to treat severe medically intractable seizures, there remains controversy as to when, or even if, the surgery should be done. Unlike most surgical therapies for epilepsy where the epileptic focus is removed, corpus callosotomy interrupts the propagation of epileptic discharges. The procedure is primarily used in patients with secondarily generalized seizures with or without drop attacks in whom focal resection is not possible. The goal of this surgery is to improve functioning and well-being. In this study, we retrospectively reviewed records from 28 patients undergoing corpus callosotomy to assess improvement following surgery. Parents and patients were also sent a questionnaire to assess quality of life. While surgery reduced the frequency of seizures, definite improvements in quality of life were limited only to patients with frequent daily drop attacks preoperatively. We believe corpus callosotomy offers a significant improvement of both seizure control and quality of life in children with frequent drop attacks of tonic, myoclonic, or atonic origin. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
