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| 类叶升麻的化学成分研究 | |
| 引用本文： | 高璟春,张金超,陈瑶,杨梦苏,肖培根.类叶升麻的化学成分研究[J].中国中药杂志,2007,32(21):2256-2259. |
| 作者姓名： | 高璟春 张金超 陈瑶 杨梦苏 肖培根 |
| 作者单位： | 1. 中国医学科学院,中国协和医科大学,药用植物研究所,北京,100094;香港城市大学,深圳研究院,广东,深圳,518057 2. 香港城市大学,生物及化学系,香港;河北大学,化学与环境科学学院,化学系,河北,保定,071002 3. 香港城市大学,深圳研究院,广东,深圳,518057 4. 香港城市大学,深圳研究院,广东,深圳,518057;香港城市大学,生物及化学系,香港 5. 中国医学科学院,中国协和医科大学,药用植物研究所,北京,100094 |
| 摘 要： | 目的：研究我国药用植物类叶升麻Actaea asiatica 根茎的化学成分,为阐明其有效成分提供依据。方法：利用硅胶柱色谱,反相柱色谱,半制备液相进行分离,根据化合物的光谱数据(IR,MS,1H-NMR,13C-NMR)和化学方法鉴定其结构。结果：从根茎的醋酸乙酯萃取物中分离得到6个化合物,分别鉴定为25-O-乙酰升麻醇(1),12β-羟基升麻醇(2),23-epi-26-deoxyactein(3),27-deoxyacetylacteol(4),26-deoxycimicifugenin(5)及β-谷甾醇(6)。结论：以上化合物均为首次从该属植物中分离得到。 |
| 关 键 词： | 类叶升麻 化学成分 |
| 文章编号： | 1001-5302（2007）21-2256-04 |
| 收稿时间： | 2006-11-23 |
| 修稿时间： | 2006年11月23 |
Study on chemical constituents from rhizomes of Actaea asiatica |
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| GAO Jing-chun; ZHANG Jin-chao; CHEN Yao; YANG Meng-su; XIAO Pei-gen.Study on chemical constituents from rhizomes of Actaea asiatica[J].China Journal of Chinese Materia Medica,2007,32(21):2256-2259. | |
| Authors: | GAO Jing-chun; ZHANG Jin-chao; CHEN Yao; YANG Meng-su; XIAO Pei-gen |
| Institution: | Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100094, China. |
| Abstract: | OBJECTIVE: To investigate the chemical constituents of the rhizomes of Actaea asiatica in order to obtain a more comprehensive understanding of its effective components. METHOD: Compounds were separated by silica gel chromatography, RP-C18 chromatography and semi-preparative high performance liquid chromatography, and their structures were established by spectral analysis and chemical evidence. RESULT: Six compounds were isolated from the ethyl acetate extract. Their structures were identified as 25-O-acetylcimigenol (1), 12beta-hydroxycimigenol (2), 23-epi-26-deoxyactein (3), 27-deoxyacetylacteol (4), 26-deoxycimicifugenin (5) and beta-sitosterol (6). CONCLUSION: All these compounds mentioned above were isolated from the plant for the first time. |
| Keywords: | Actaea asiatica chemical constituents |
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