Synthesis and cytotoxic activity of N-(2-chloroethyl)-N-nitroureas and N-(2-chloroethyl)-N-nitrocarbamates |
| |
Authors: | Botyánszki J Bódi J Stratford I J Süli-Vargha H |
| |
Affiliation: | Research Group for Peptide Chemistry, Hungarian Academy of Sciences, E?tv?s Lorand University, Budapest. |
| |
Abstract: | As analogs of the widely used anti-tumor agents, N-(2-chloroethyl)-N-nitrosoureas, N-(2-chloroethyl)-N-nitroureas and N-(2-chloroethyl)-N-nitrocarbamates were synthesized by nitration following the reaction of the appropriate amines or alcohols with 2-chloroethyl isocyanate. All tested compounds exert cytotoxic effect with IC50 values of 10(-4) to 10(-6) M and most of them show somewhat higher cytotoxicity in nitrogen than in air. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|