Cell proliferation in human tumours growing in nude mice: renal cell carcinomas,larynx and hypopharynx carcinomas |
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Authors: | Brigitte Maurer-Schultze Ioannis D Bassukas Michael Böswald Markus Harasim |
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Institution: | (1) Institut für Medizinische Strahlenkunde, University of Würzburg, Versbacher Strasse 5, W-8700 Würzburg, Federal Republic of Germany |
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Abstract: | Summary Cell proliferation of 51 human renal cell carcinomas and 9 larynx and hypopharynx carcinomas has been studied in vitro and using xenotransplants. The proliferative activity (3H]thymidine labelling index) increases during the first passages in nude mice and then remains almost constant throughout subsequent passages. A comparison of cell kinetic parameters of 8 human renal cell carcinomas, 1 hypopharynx and 2 larynx carcinomas, with data of xenografts and of human tumours in situ published up to now, shows that the cell kinetic parameters of human tumour xenografts presently studied range between those of human tumours in situ and those of autochthonous or transplantable mouse tumours. S-phase durations and potential doubling times are considerably shorter in xenotransplants than in human tumours in situ, whereas the cycle time is about the same. This means that the growth fraction increases considerably after xenotransplantation. This change of human tumour cell proliferation after transplantation into nude mice should be kept in mind if one wishes to draw conclusions from the nude mouse model on conditions in human beings, particularly with respect to therapeutic regimens, which are frequently tested in the nude mouse model.Abbreviations used RCC
renal cell carcinoma
- HPC
larynx or hypopharynx carcinoma
- LI
labelling index
- PLM
percentage of labelled mitoses
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t
s
S-phase duration
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t
c
cycle time
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t
pot
potential doubling time
This work was supported by the Deutsche Forschungsgemeinschaft (Ma 876/2-1) |
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Keywords: | Human tumours Nude mice Cell proliferation |
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